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February 2023

Prof. Maria Jesus Vicent “Designing Personalized Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients”

February 27, 2023 @ 4:30 pm
ISIS – Salle de conférence

Prof. Maria Jesus Vicent Polymer Therapeutics Lab, Prince Felipe Research Center (CIPF) Valencia, Spain Abstract Breast cancer, the most prevalent tumor in women worldwide1, still lacks effective treatment approaches that increase survival rates and reduce side effects. The implementation of polypeptide-based polymer-drug conjugation strategies represents a promising approach2. The physico-chemical parameters of a polypeptide-conjugate, and hence its biological performance, are defined by an intricate interplay of multiple structural factors. This highlights the need for detailed structure-activity relationship studies to develop…

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March 2023

Jean-François LUTZ “The Languages of Synthetic Polymers”

March 6, 2023 @ 4:30 pm
ISIS – Salle de conférence

Jean-François LUTZ Institut de Science et d’Ingénierie Supramoléculaires, Université de Strasbourg, CNRS UMR 7006, France.   Abstract It has been shown in recent years that information can be stored at the molecular level in synthetic polymers . To achieve such a property, different comonomers are used as a molecular alphabet and assembled together into a defined information sequence. For instance, an alphabet based on two different monomers allows writing of binary information in a linear polymer chain . But, of…

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Prof. Bettina Lotsch “Optoelectronics meets optoionics: energy conversion and light storage in 2d carbon nitrides “

March 13, 2023 @ 4:30 pm
ISIS – Salle de conférence

Prof. Bettina Lotscht Max Planck Institute for Solid State Research and University of Munich (LMU) Abstract Utilization and storage of intermittent energy resources such as wind or solar power is a cornerstone of a renewable energy infrastructure. To meet this challenge, new material concepts are vital. Using the light and dark reactions of natural photosynthesis as a blueprint, we have identified a new generation of “light storing” molecular materials that can both convert and store solar energy via trapping of…

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June 2023

Prof Jonathan Clayden “Dynamic Foldamers: Controlling Molecular Motion for Biomimetic Function”

June 7, 2023 @ 4:30 pm
ISIS – Salle de conférence

Prof Jonathan Clayden School of Chemistry - University of Bristol   Abstract Biology presents many challenges for the chemist to tackle, and 20th century synthetic chemistry made great advances in building the molecular structures of nature. A new target for synthesis is the mimicry of biological molecular function – for example the ability to manipulate and communicate information using complex molecular interactions and induced conformational changes, or to induce reactivity through fine control of molecular orientation. This lecture will describe…

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September 2023

Prof. Adrian Salic “How cells send and receive messages”

September 25, 2023 @ 4:00 pm
ISIS – Salle de conférence

Prof. Adrian Salic Harvard Medical School About Prof Adrian Salic Abstract Communication between cells is essential for all multicellular organisms, both during their embryonic development and in adult life. Cells send and receive signals continuously, thus responding to their environment and coordinating their behavior. Surprisingly, all communication between animal cells is carried out by a relatively small number of conserved signaling pathways (about 20), each consisting of an ordered chain of biochemical steps that link various extracellular inputs with specific…

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October 2023

Prof Darren J. Dixon “New Catalytic Approaches for Simplifying Complex Molecule Synthesis”

October 9, 2023 @ 4:00 pm
ISIS – Salle de conférence

Darren J. Dixon Chemistry Research Laboratory, Department of Chemistry, University of Oxford, UK   Abstract New catalysts are key for unlocking previously unknown molecular reactivity and unexplored chemical space, as well as governing the 3-dimensional structure of product molecules of interest to chemistry, biology and medicine. In this lecture, new synthetically relevant chemistry linked to two distinct types of catalyst systems will presented. In the first part, recent developments from our group for the direct synthesis of alpha and beta-functionalised…

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November 2023

Bilateral symposium Jilin University – ISIS

November 6, 2023 @ 9:00 am - 5:30 pm
ISIS – Salle de conférence

Monday, November 6, 2023 program

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Prof. Phil Holliger on November

November 29, 2023 @ 4:30 pm
ISIS – Salle de conférence

Prof. Phil Holliger UKRI MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK   Abstract Synthetic biology seeks to probe fundamental aspects of biological form and function by construction (i.e. resynthesis) rather than deconstruction (analysis). Synthesis thus complements analytic studies, and allows novel approaches towards fundamental biological questions. We have been exploiting the synthesis paradigm to explore the chemical etiology of the genetic apparatus shared by all life on earth, specifically the synthesis, reverse…

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January 2024

Dr. Beatrice Adelizzi “Tuning non-covalent interactions: from synthetic supramolecular copolymers to proteins and DNA”

January 17 @ 3:30 pm
ISIS – Salle de conférence

Beatrice Adelizzi Project Leader - Inkjet Synthesis at DNA Script Abstract Despite being inherently weak and dynamic, non-covalent interactions play a fundamental role in dictating the organization of molecules, materials, and (bio)polymers. Understanding such interactions allows one to tune their strength, predict the self-organization of the system, and enhance (or inhibit) targeted reactivities. Despite the wealth of research in the field of supramolecular chemistry, the challenge of mastering a system becomes exponentially more difficult as its complexity is increased. This…

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March 2024

Prof. Simone Fabiano “Organic Mixed Conductors for Brain-Inspired Electronics”

March 27 @ 4:30 pm
ISIS – Salle de conférence

Prof. Simone Fabiano Linköping University, Sweden   Abstract Biointegrated neuromorphic hardware holds promise for new protocols to record and regulate signaling in biological systems. Traditional neuromorphic systems relying on silicon face limitations in bio-integration due to circuit complexity, poor biocompatibility, and low energy efficiency. Organic mixed ionic-electronic conductors (OMIECs), owing to their structural resemblance to biomolecules and coupled ionic-electronic transport functionalities, offer an excellent solution for bridging electronics and biology, facilitating energy-efficient signal transduction. In this presentation, I will explore…

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