A collaboration between two ISIS research groups (Lehn, Samori) has revealed dynamic covalent chemistry on surfaces. They state: “The results above taken together stress the crucial role of interactions with the surface as the selection force that drives the outcome of covalent chemical reactions, allowing or inhibiting given transformations and thus leads to a surface-controlled product formation and reaction selectivity that is essentially different from the product distribution observed in solution.” Check out the full publication here.