Programme
14h30 - 15h30 Conférence d'Adrian SALIC
15h30 - 16h00 Pause-café
16h00 - 17h00 Conférence de Pascal MAYER
Adrian SALIC, professeur à la Harvard Medical School (USA) et à l'Université de Strasbourg - Institut de Science et d'Ingénierie Supramoléculaires (UMR 7006)
Title: Cellular communication in development, disease and evolution
Abstract:
Each human being consists of tens of trillions of cells, all of them derived from one initial cell, the fertilized egg. More broadly, all life on Earth is descended from a single ancestral cell that lived about 4 billion years ago. The cells of an organism communicate continuously via biochemical signals, responding to their environment and coordinating their behaviors. Cellular communication is essential for the proper functioning of the organism and is precisely controlled, to avoid negative consequences such as birth defects (caused by insufficient communication during development) or cancer (due to excessive communication). I will illustrate the basic principles of cellular communication, and its role in embryogenesis, the daily functioning of the body and in evolution. I will also discuss how understanding of these processes can be used to develop drugs against cancer.
Pascal MAYER, professeur conventionné à l’Université de Strasbourg - Institut de Science et d'Ingénierie Supramoléculaires (UMR 7006) et Co-fondateur de PDG d'Alphanosos, chaire honoraire de l'Institut d’études avancées de l’Université de Strasbourg (USIAS), lauréat du Breakthrough Prize et du Gairdner Award
Title: Pluridisciplinarity at Work: From Next Generation DNA Sequencing to Next Generation Therapeutics
Abstract:
Scientific breakthroughs often emerge at the intersection of disciplines. From the conceptual inception of Next Generation Sequencing (NGS) to the development of Next Generation Therapeutics, this talk highlights the power of transdisciplinary thinking. The Lemanic branch of NGS played a crucial but often overlooked role in revolutionizing DNA sequencing, laying the groundwork for modern genomics. Moving beyond sequencing, traditional drug discovery faces limitations due to toxicity, resistance, and inefficacy. At Alphanosos, we use AI-driven network polypharmacology to design synergistic botanical mixes that are safe, effective, and sustainable. Our ICLEDA DNA amplification technology also opens new possibilities for DNA computing-based artificial brains, offering low-power, EM-resistant bio-inspired computing. By integrating genomics, AI, and drug discovery, we challenge conventional paradigms in both medicine and computation. This presentation showcases how cross-disciplinary innovation is key to tackling healthcare challenges and shaping the future of technology.
