Programme
18 Mai, 2026 → Lecture 1 à 16h30
Advances in HAT Catalysis for Olefin Functionalization
The lecture will focus on recent developments in the group involving hydrogen atom transfer reactions (HAT) for the hydrofunctionalization of olefins. Inspired by the pioneering work of Mukaiyama, some years ago we introduced novel olefin hydro -azidation, -hydrazination, -chlorination, and -cyanation, among other transformations that were catalyzed by manganese and cobalt complexes. More recently, we have significantly advanced the chemistry of the catalysts to enable simplified, efficient versions of these isohypsic reactions as well as an expanded set of transformations. In particular, processes have been devised that effect a host of olefin functionalization reactions without the need for many of the traditionally employed stochiometric additives (oxidants and reductants). Key to the discoveries are deep-seated mechanistic analysis that led to the incorporation of photoirradiation in the execution of the reactions, which has led to a new broad class of photHAT transformations.
19 Mai, 2026 → Lecture 2 à 16h30
New Strategies and Tactics for Synthesis: Merging Total Synthesis and Methodology
The presentation will include discussion and analysis of recent natural product targets that have been synthesized in the group and accompanying methods development. It will focus on target-oriented synthesis as an engine for the generation of novel methods and approaches to target molecules with a focus on sustainability. The methods involve novel, unexpected reactivity and unusual building blocks that are fully integrated to lead to efficient routes. Examples will be drawn from recently completed syntheses of Euphorikanin A, Pedrolide, Crokonoid A, Dhilirolide, and Novofumigatonin.
Pour plus d'information
Organisateur Giulio RAGAZZON
