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May 2017

Dr. Martin Blackledge “NMR studies of protein dynamics – from fundamental biophysics to biological function”

May 29 @ 4:30 pm
ISIS,

NMR STUDIES OF Protein DYNAMICS – from fundamental biophysics TO BIOLOGICAL function Martin Blackledge Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale, Grenoble   martin.blackledge@ibs.fr The precision with which X-ray crystallography and electron microscopy provides structural models of biologically active protein conformations belies an easily overlooked dilemma. Proteins are inherently dynamic, exhibiting conformational freedom on many timescales,1 implicating structural rearrangements that play a major role in molecular interaction, thermodynamic stability and molecular recognition and signalling. Static structural biology…

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Prof. Dirk Schwarzer “Chemical tools for chromatin-modifying enzymes”

May 30 @ 4:30 pm
ISIS,

Chemical tools for chromatin-modifying enzymes Prof. Dirk Schwarzer Interfaculty Institute of Biochemistry, University of Tübingen Tübingen/Germany Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins are crucial signaling events directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Histone deacetylases (HDACs) interact with chromatin…

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June 2017

Prof.Dr.María Vallet Regí “Design of drug nanocarriers”

June 12 @ 4:30 pm
ISIS,

Prof.Dr.María Vallet Regí Grupo de Investigación Biomateriales Inteligentes GIBI-CIBER-BBN Dpto. Química Inorgánica y Bioinorgánica Fac. Farmacia – UCM Madrid – España http://www.ucm.es/valletregigroup https://vimeo.com/190054397   titre : Design of drug nanocarriers' description : This lecture will describe the production of smart nanosystems capable of: carrying antitumor agents selectively to a tumor tissue, and  releasing them there thanks to the application of an external stimulus. We use the term smart because those nanocarriers are able to release the drugs when and where…

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