2008 |
Adamovic, Ivana ; Mijailovich, Srboljub M; Karplus, Martin The elastic properties of the structurally characterized myosin II s2 subdomain: A molecular dynamics and normal mode analysis Journal Article In: BIOPHYSICAL JOURNAL, 94 (10), pp. 3779–3789, 2008, ISSN: 0006-3495. @article{adamovic_elastic_2008, title = {The elastic properties of the structurally characterized myosin II s2 subdomain: A molecular dynamics and normal mode analysis}, author = {Adamovic, Ivana and Mijailovich, Srboljub M. and Karplus, Martin}, doi = {10.1529/biophysj.107.122028}, issn = {0006-3495}, year = {2008}, date = {2008-05-01}, journal = {BIOPHYSICAL JOURNAL}, volume = {94}, number = {10}, pages = {3779--3789}, abstract = {The elastic properties (stretching and bending moduli) of myosin are expected to play an important role in its function. Of particular interest is the extended alpha-helical coiled-coil portion of the molecule. Since there is no high resolution structure for the entire coiled-coil, a study is made of the scallop myosin II S2 subdomain for which an x-ray structure is available (Protein Data Bank 1nkn). We estimate the stretching and bending moduli of the S2 subdomain with an atomic level model by use of molecular simulations. Results were obtained from nonequilibrium molecular dynamics simulations in the presence of an external force, from the fluctuations in equilibrium molecular dynamics simulations and from normal modes. In addition, a poly-Ala (78 amino acid residues) alpha-helix model was examined to test the methodology and because of its interest as part of the lever arm. As expected, both the alpha-helix and coiled-coil S2 subdomain are very stiff for stretching along the main axis, with the stretching stiffness constant in the range 60-80 pN/nm (scaled to the 60 nm long S2). Both molecules are much more flexible for bending with a lateral stiffness of similar to 0.010pN/nm for the S2 and 0.0055pN/nm for the alpha-helix (scaled to 60 nm). These results are expected to be useful in estimating cross-bridge elasticity, which is required for understanding the strain-dependent transitions in the actomyosin cycle and for the development of three-dimensional models of muscle contraction.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The elastic properties (stretching and bending moduli) of myosin are expected to play an important role in its function. Of particular interest is the extended alpha-helical coiled-coil portion of the molecule. Since there is no high resolution structure for the entire coiled-coil, a study is made of the scallop myosin II S2 subdomain for which an x-ray structure is available (Protein Data Bank 1nkn). We estimate the stretching and bending moduli of the S2 subdomain with an atomic level model by use of molecular simulations. Results were obtained from nonequilibrium molecular dynamics simulations in the presence of an external force, from the fluctuations in equilibrium molecular dynamics simulations and from normal modes. In addition, a poly-Ala (78 amino acid residues) alpha-helix model was examined to test the methodology and because of its interest as part of the lever arm. As expected, both the alpha-helix and coiled-coil S2 subdomain are very stiff for stretching along the main axis, with the stretching stiffness constant in the range 60-80 pN/nm (scaled to the 60 nm long S2). Both molecules are much more flexible for bending with a lateral stiffness of similar to 0.010pN/nm for the S2 and 0.0055pN/nm for the alpha-helix (scaled to 60 nm). These results are expected to be useful in estimating cross-bridge elasticity, which is required for understanding the strain-dependent transitions in the actomyosin cycle and for the development of three-dimensional models of muscle contraction. |
Maragakis, Paul ; Spichty, Martin ; Karplus, Martin A differential fluctuation theorem Journal Article In: JOURNAL OF PHYSICAL CHEMISTRY B, 112 (19), pp. 6168–6174, 2008, ISSN: 1520-6106. @article{maragakis_differential_2008, title = {A differential fluctuation theorem}, author = {Maragakis, Paul and Spichty, Martin and Karplus, Martin}, doi = {10.1021/jp077037r}, issn = {1520-6106}, year = {2008}, date = {2008-05-01}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, volume = {112}, number = {19}, pages = {6168--6174}, abstract = {We derive a nonequilibrium thermodynamics identity (the “differential fluctuation theorem”) that connects forward and reverse joint probabilities of nonequilibrium work and of arbitrary generalized coordinates corresponding to states of interest. This identity allows us to estimate the free energy difference between domains of these states. Our results follow from a general symmetry relation between averages over nonequilibrium forward and backward path functions derived by Crooks [Crooks, G. E. Phys. Rev. E 2000, 61, 2361-2366]. We show how several existing nonequilibrium thermodynamic identities can be obtained directly from the differential fluctuation theorem. We devise an approach for measuring conformational free energy differences, and we demonstrate its applicability to the analysis of molecular dynamics simulations by estimating the free energy difference between two conformers of the alanine dipeptide model system. We anticipate that these developments can be applied to the analysis of laboratory experiments.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We derive a nonequilibrium thermodynamics identity (the “differential fluctuation theorem”) that connects forward and reverse joint probabilities of nonequilibrium work and of arbitrary generalized coordinates corresponding to states of interest. This identity allows us to estimate the free energy difference between domains of these states. Our results follow from a general symmetry relation between averages over nonequilibrium forward and backward path functions derived by Crooks [Crooks, G. E. Phys. Rev. E 2000, 61, 2361-2366]. We show how several existing nonequilibrium thermodynamic identities can be obtained directly from the differential fluctuation theorem. We devise an approach for measuring conformational free energy differences, and we demonstrate its applicability to the analysis of molecular dynamics simulations by estimating the free energy difference between two conformers of the alanine dipeptide model system. We anticipate that these developments can be applied to the analysis of laboratory experiments. |
Ruff, Yves ; Lehn, Jean-Marie Glycodynamers: Dynamic analogs of arabinofuranoside oligosaccharides Journal Article In: BIOPOLYMERS, 89 (5), pp. 486–496, 2008, ISSN: 0006-3525. @article{ruff_glycodynamers:_2008, title = {Glycodynamers: Dynamic analogs of arabinofuranoside oligosaccharides}, author = {Ruff, Yves and Lehn, Jean-Marie}, doi = {10.1002/bip.20885}, issn = {0006-3525}, year = {2008}, date = {2008-05-01}, journal = {BIOPOLYMERS}, volume = {89}, number = {5}, pages = {486--496}, abstract = {Dynamic analogs of alpha-(1 -textbackslashtextbackslashtextgreater 5)-D-oligoarabinofuranosides were prepared by oxime polycondensation. These equilibrium polymers were characterized by H-1 NMR studies, NMR DOSY, and MALDI mass spectrometry. Their reversibility under mild acidic conditions was demonstrated by component exchange reaction followed by 1H NMR studies. Their size and composition can be tuned by component exchange emphasizing their constitutionally dynamic character. They represent dynamic versions of biopolymers, biodynamers. (c) 2007 Wiley Periodicals, Inc.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Dynamic analogs of alpha-(1 -textbackslashtextbackslashtextgreater 5)-D-oligoarabinofuranosides were prepared by oxime polycondensation. These equilibrium polymers were characterized by H-1 NMR studies, NMR DOSY, and MALDI mass spectrometry. Their reversibility under mild acidic conditions was demonstrated by component exchange reaction followed by 1H NMR studies. Their size and composition can be tuned by component exchange emphasizing their constitutionally dynamic character. They represent dynamic versions of biopolymers, biodynamers. (c) 2007 Wiley Periodicals, Inc. |
Petitjean, Anne ; Cuccia, Louis A; Schmutz, Marc ; Lehn, Jean-Marie Naphthyridine-based helical foldamers and macrocycles: Synthesis, cation binding, and supramolecular assemblies Journal Article In: JOURNAL OF ORGANIC CHEMISTRY, 73 (7), pp. 2481–2495, 2008, ISSN: 0022-3263. @article{petitjean_naphthyridine-based_2008, title = {Naphthyridine-based helical foldamers and macrocycles: Synthesis, cation binding, and supramolecular assemblies}, author = {Petitjean, Anne and Cuccia, Louis A. and Schmutz, Marc and Lehn, Jean-Marie}, doi = {10.1021/jo702495u}, issn = {0022-3263}, year = {2008}, date = {2008-04-01}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, volume = {73}, number = {7}, pages = {2481--2495}, abstract = {Unraveling the factors that control the conformation of molecular chains is of great interest both for understanding the shape of biological molecular strands and for designing artificial ones that adopt desired forms. Thus, a variety of artificial folding codons have been identified that enforce the formation, among others, of helices, strands, and loops, the major emphasis being on the shape of the foldamer. We report herein the synthesis and study of a family of foldamers and macrocycles based on the 1,8-naphthyridine and pyrimidine units, whose internal cavity is large enough to accommodate ionic substrates, and focus on the impact of guest binding within a cylindrical environment. Interestingly, the binding event within these large oligomers is translated to the outside of the receptors and affects the interaction of the overall complexes with the outside world. For instance, alkali cations bind to the one-turn helices and macrocycles to promote fibril formation and aggregation. Also, polyammonium substrates are able to tune the length of the overall helix assemblies and the rigidity of long oligomers. The reported data on one-turn, two-turn helices and macrocycles not only allows one to devise a model for the ion-controlled supramolecular assembly of such systems but also provides evidence that such controlled scaffolds bear promise in the design of complex systems.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Unraveling the factors that control the conformation of molecular chains is of great interest both for understanding the shape of biological molecular strands and for designing artificial ones that adopt desired forms. Thus, a variety of artificial folding codons have been identified that enforce the formation, among others, of helices, strands, and loops, the major emphasis being on the shape of the foldamer. We report herein the synthesis and study of a family of foldamers and macrocycles based on the 1,8-naphthyridine and pyrimidine units, whose internal cavity is large enough to accommodate ionic substrates, and focus on the impact of guest binding within a cylindrical environment. Interestingly, the binding event within these large oligomers is translated to the outside of the receptors and affects the interaction of the overall complexes with the outside world. For instance, alkali cations bind to the one-turn helices and macrocycles to promote fibril formation and aggregation. Also, polyammonium substrates are able to tune the length of the overall helix assemblies and the rigidity of long oligomers. The reported data on one-turn, two-turn helices and macrocycles not only allows one to devise a model for the ion-controlled supramolecular assembly of such systems but also provides evidence that such controlled scaffolds bear promise in the design of complex systems. |
Frey, Julien ; Tock, Christian ; Collin, Jean-Paul ; Heitz, Valerie ; Sauvage, Jean-Pierre A [3]rotaxane with two porphyrinic plates acting as an adaptable receptor Journal Article In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (14), pp. 4592+, 2008, ISSN: 0002-7863. @article{frey_[3]rotaxane_2008, title = {A [3]rotaxane with two porphyrinic plates acting as an adaptable receptor}, author = {Frey, Julien and Tock, Christian and Collin, Jean-Paul and Heitz, Valerie and Sauvage, Jean-Pierre}, doi = {10.1021/ja7110493}, issn = {0002-7863}, year = {2008}, date = {2008-04-01}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, volume = {130}, number = {14}, pages = {4592+}, abstract = {Following a multistep procedure, the copper(I)-templated strategy allowed preparation of a multifunctional [3]rotaxane. The dumbbell consists of a central two-bidentate chelate unit and two terminal stoppers. The two rings threaded on the rotaxane axis consist each of a 1,10-phenanthroline- incorporating macrocycle, rigidly connected to an appended zinc-complexed porphyrin. The copper(I) template can be removed, affording a free rotaxane whose two rings can glide freely along the axis and spin around it. The dumbbell being very long (similar to 85 A in its extended conformation from one stopper to the other), the porphyrin-porphyrin distance can be varied over a wide range. The two porphyrinic plates constitute the key elements of a receptor able to complex various guests between the plates. The ability of the threaded rings to move freely makes the host perfectly adjustable, allowing capture of geometrically very different guests. The copper(I)-complexed rotaxane also acts as an efficient receptor, although its adaptability is obviously more limited than that of its free rotaxane counterpart.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Following a multistep procedure, the copper(I)-templated strategy allowed preparation of a multifunctional [3]rotaxane. The dumbbell consists of a central two-bidentate chelate unit and two terminal stoppers. The two rings threaded on the rotaxane axis consist each of a 1,10-phenanthroline- incorporating macrocycle, rigidly connected to an appended zinc-complexed porphyrin. The copper(I) template can be removed, affording a free rotaxane whose two rings can glide freely along the axis and spin around it. The dumbbell being very long (similar to 85 A in its extended conformation from one stopper to the other), the porphyrin-porphyrin distance can be varied over a wide range. The two porphyrinic plates constitute the key elements of a receptor able to complex various guests between the plates. The ability of the threaded rings to move freely makes the host perfectly adjustable, allowing capture of geometrically very different guests. The copper(I)-complexed rotaxane also acts as an efficient receptor, although its adaptability is obviously more limited than that of its free rotaxane counterpart. |
Strutt, Nathan L; Sauvage, Jean-Pierre PRES 17-Synthesis of a tetra-substituted porphyrin for use in a [6]rotaxane reminiscent of a press Journal Article In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 235 , 2008, ISSN: 0065-7727. @article{strutt_pres_2008, title = {PRES 17-Synthesis of a tetra-substituted porphyrin for use in a [6]rotaxane reminiscent of a press}, author = {Strutt, Nathan L. and Sauvage, Jean-Pierre}, issn = {0065-7727}, year = {2008}, date = {2008-04-01}, journal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY}, volume = {235}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Lopez-Tejeira, F; Rodrigo, Sergio G; Martin-Moreno, L; Garcia-Vidal, F J; Devaux, E; Dintinger, J; Ebbesen, T W; Krenn, J R; Radko, I P; Bozhevolnyi, S I; Gonzalez, M U; Weeber, J C; Dereux, A Modulation of surface plasmon coupling-in by one-dimensional surface corrugation Journal Article In: NEW JOURNAL OF PHYSICS, 10 , 2008, ISSN: 1367-2630. @article{lopez-tejeira_modulation_2008, title = {Modulation of surface plasmon coupling-in by one-dimensional surface corrugation}, author = {Lopez-Tejeira, F. and Rodrigo, Sergio G. and Martin-Moreno, L. and Garcia-Vidal, F. J. and Devaux, E. and Dintinger, J. and Ebbesen, T. W. and Krenn, J. R. and Radko, I. P. and Bozhevolnyi, S. I. and Gonzalez, M. U. and Weeber, J. C. and Dereux, A.}, doi = {10.1088/1367-2630/10/3/033035}, issn = {1367-2630}, year = {2008}, date = {2008-03-01}, journal = {NEW JOURNAL OF PHYSICS}, volume = {10}, abstract = {Surface plasmon-polaritons have recently attracted renewed interest in the scientific community for their potential in sub-wavelength optics, light generation and non-destructive sensing. Given that they cannot be directly excited by freely propagating light due to their intrinsic binding to the metal surface, the light - plasmon coupling efficiency becomes of crucial importance for the success of any plasmonic device. Here, we present a comprehensive study on the modulation ( enhancement or suppression) of such a coupling efficiency by means of one-dimensional surface corrugation. Our approach is based on simple wave interference and enables us to make quantitative predictions which have been experimentally confirmed at both the near-infrared and telecom ranges.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Surface plasmon-polaritons have recently attracted renewed interest in the scientific community for their potential in sub-wavelength optics, light generation and non-destructive sensing. Given that they cannot be directly excited by freely propagating light due to their intrinsic binding to the metal surface, the light - plasmon coupling efficiency becomes of crucial importance for the success of any plasmonic device. Here, we present a comprehensive study on the modulation ( enhancement or suppression) of such a coupling efficiency by means of one-dimensional surface corrugation. Our approach is based on simple wave interference and enables us to make quantitative predictions which have been experimentally confirmed at both the near-infrared and telecom ranges. |
Wenger, Jerome ; Gerard, Davy ; Dintinger, Jose ; Mahboub, Oussama ; Bonod, Nicolas ; Popov, Evgeny ; Ebbesen, Thomas W; Rigneault, Herve E Emission and excitation contributions to enhanced single molecule fluorescence by gold nanometric apertures Journal Article In: OPTICS EXPRESS, 16 (5), pp. 3008–3020, 2008, ISSN: 1094-4087. @article{wenger_emission_2008, title = {Emission and excitation contributions to enhanced single molecule fluorescence by gold nanometric apertures}, author = {Wenger, Jerome and Gerard, Davy and Dintinger, Jose and Mahboub, Oussama and Bonod, Nicolas and Popov, Evgeny and Ebbesen, Thomas W. and Rigneault, Herve E.}, doi = {10.1364/OE.16.003008}, issn = {1094-4087}, year = {2008}, date = {2008-03-01}, journal = {OPTICS EXPRESS}, volume = {16}, number = {5}, pages = {3008--3020}, abstract = {We detail the role of single nanometric apertures milled in a gold film to enhance the fluorescence emission of Alexa Fluor 647 molecules. Combining fluorescence correlation spectroscopy and lifetime measurements, we determine the respective contributions of excitation and emission in the observed enhanced fluorescence. We characterize a broad range of nanoaperture diameters from 80 to 310 nm, and highlight the link between the fluorescence enhancement and the local photonic density of states. These results are of great interest to increase the effectiveness of fluorescence-based single molecule detection and to understand the interaction between a quantum emitter and a nanometric metal structure. (C) 2008 Optical Society of America.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We detail the role of single nanometric apertures milled in a gold film to enhance the fluorescence emission of Alexa Fluor 647 molecules. Combining fluorescence correlation spectroscopy and lifetime measurements, we determine the respective contributions of excitation and emission in the observed enhanced fluorescence. We characterize a broad range of nanoaperture diameters from 80 to 310 nm, and highlight the link between the fluorescence enhancement and the local photonic density of states. These results are of great interest to increase the effectiveness of fluorescence-based single molecule detection and to understand the interaction between a quantum emitter and a nanometric metal structure. (C) 2008 Optical Society of America. |
Baudrion, Anne-Laure ; de Leon-Perez, Fernando ; Mahboub, Oussama ; Hohenau, Andreas ; Ditlbacher, Harald ; Garcia-Vidal, Francisco J; Dintinger, Jose ; Ebbesen, Thomas W; Martin-Moreno, Luis ; Krenn, Joachim R Coupling efficiency of light to surface plasmon polariton for single subwavelength holes in a gold film Journal Article In: OPTICS EXPRESS, 16 (5), pp. 3420–3429, 2008, ISSN: 1094-4087. @article{baudrion_coupling_2008, title = {Coupling efficiency of light to surface plasmon polariton for single subwavelength holes in a gold film}, author = {Baudrion, Anne-Laure and de Leon-Perez, Fernando and Mahboub, Oussama and Hohenau, Andreas and Ditlbacher, Harald and Garcia-Vidal, Francisco J. and Dintinger, Jose and Ebbesen, Thomas W. and Martin-Moreno, Luis and Krenn, Joachim R.}, doi = {10.1364/OE.16.003420}, issn = {1094-4087}, year = {2008}, date = {2008-03-01}, journal = {OPTICS EXPRESS}, volume = {16}, number = {5}, pages = {3420--3429}, abstract = {sThe excitation of surface plasmon polaritons (SPP) by focusing a laser beam on single subwavelength holes opened in a thin gold film is studied both experimentally and theoretically. By means of leakage radiation microscopy, quantitative measurements of the light-SPP coupling efficiency are performed for holes with different sizes and shapes. The system is studied theoretically by using a modal expansion method to calculate the fraction of the incident energy which is scattered by the hole into a surface plasmon. We demonstrate that a single subwavelength hole can be used to generate SPP with an efficiency up to 28%. (C) 2008 Optical Society of America.}, keywords = {}, pubstate = {published}, tppubtype = {article} } sThe excitation of surface plasmon polaritons (SPP) by focusing a laser beam on single subwavelength holes opened in a thin gold film is studied both experimentally and theoretically. By means of leakage radiation microscopy, quantitative measurements of the light-SPP coupling efficiency are performed for holes with different sizes and shapes. The system is studied theoretically by using a modal expansion method to calculate the fraction of the incident energy which is scattered by the hole into a surface plasmon. We demonstrate that a single subwavelength hole can be used to generate SPP with an efficiency up to 28%. (C) 2008 Optical Society of America. |
Laux, Eric ; Genet, Cyriaque ; Skauli, Torbjorn ; Ebbesen, Thomas W Plasmonic photon sorters for spectral and polarimetric imaging Journal Article In: NATURE PHOTONICS, 2 (3), pp. 161–164, 2008, ISSN: 1749-4885. @article{laux_plasmonic_2008, title = {Plasmonic photon sorters for spectral and polarimetric imaging}, author = {Laux, Eric and Genet, Cyriaque and Skauli, Torbjorn and Ebbesen, Thomas W.}, doi = {10.1038/nphoton.2008.1}, issn = {1749-4885}, year = {2008}, date = {2008-03-01}, journal = {NATURE PHOTONICS}, volume = {2}, number = {3}, pages = {161--164}, abstract = {Colour cameras mimic the human eye and record only a small part of the information contained in the incoming light. Modern image sensing techniques, which subdivide the light spectrally or record information about the polarization of the incoming light, can extract much more information for applications ranging from biological studies to remote sensing(1-5). Spectral imaging techniques(6) typically rely on filters or interferometers combined with scanning or subsampling to record a spectral image `cube' ( which has wavelength as a third dimension). This leads to inefficient use of the incoming light and/ or long recording times. Here, we show that surface plasmons enable direct recording of spectral image cubes in a single exposure. By texturing metal surfaces at the nanometre scale, incoming light is converted to surface plasmons and can then be separated according to wavelength and polarization, before being recoupled to light through subwavelength apertures that illuminate individual photodetector elements. This photon- sorting capability provides a new approach for spectral and polarimetric imaging with extremely compact device archictures.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Colour cameras mimic the human eye and record only a small part of the information contained in the incoming light. Modern image sensing techniques, which subdivide the light spectrally or record information about the polarization of the incoming light, can extract much more information for applications ranging from biological studies to remote sensing(1-5). Spectral imaging techniques(6) typically rely on filters or interferometers combined with scanning or subsampling to record a spectral image `cube' ( which has wavelength as a third dimension). This leads to inefficient use of the incoming light and/ or long recording times. Here, we show that surface plasmons enable direct recording of spectral image cubes in a single exposure. By texturing metal surfaces at the nanometre scale, incoming light is converted to surface plasmons and can then be separated according to wavelength and polarization, before being recoupled to light through subwavelength apertures that illuminate individual photodetector elements. This photon- sorting capability provides a new approach for spectral and polarimetric imaging with extremely compact device archictures. |
Liscio, Andrea ; Palermo, Vincenzo ; Samori, Paolo Probing local surface potential of quasi-one-dimensional systems: A KPFM study of P3HT nanofibers Journal Article In: ADVANCED FUNCTIONAL MATERIALS, 18 (6), pp. 907–914, 2008, ISSN: 1616-301X. @article{liscio_probing_2008, title = {Probing local surface potential of quasi-one-dimensional systems: A KPFM study of P3HT nanofibers}, author = {Liscio, Andrea and Palermo, Vincenzo and Samori, Paolo}, doi = {10.1002/adfm.200701142}, issn = {1616-301X}, year = {2008}, date = {2008-03-01}, journal = {ADVANCED FUNCTIONAL MATERIALS}, volume = {18}, number = {6}, pages = {907--914}, abstract = {A new model for the quantitative analysis of Kelvin Probe Force Microscopy (KPFM) measurements of quasi-one-dimensional systems is presented. It is applied to precisely determine the local surface potential (SP) of semiconducting nanofibers of poly (3-hexylthiophene) (P3HT) self-assembled on various flat substrates. To study these quasi-one dimensional objects, the effective area has been defined. This parameter represents the area of sample surface interacting with the KPFM probe and it plays a crucial role in the estimation of the SP of nanofibers having a cross-section comparable to the apical diameter of the tip, i.e., 20 nm. Therefore our model makes it possible to gain quantitative insight into nano-systems smaller than 20 nm. In particular, through the estimation of the effective area, it allows to determine the local surface potential of single nanofiber as well as to simulate the KPFM image of nano-assemblies adsorbed both on electrically insulating and conducting substrates. This versatile model represents a useful tool to study with a high degree of precision the surface potential characteristics of nanowires paving the way towards their use as building blocks for the fabrication of electronic nanodevices with improved performance.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A new model for the quantitative analysis of Kelvin Probe Force Microscopy (KPFM) measurements of quasi-one-dimensional systems is presented. It is applied to precisely determine the local surface potential (SP) of semiconducting nanofibers of poly (3-hexylthiophene) (P3HT) self-assembled on various flat substrates. To study these quasi-one dimensional objects, the effective area has been defined. This parameter represents the area of sample surface interacting with the KPFM probe and it plays a crucial role in the estimation of the SP of nanofibers having a cross-section comparable to the apical diameter of the tip, i.e., 20 nm. Therefore our model makes it possible to gain quantitative insight into nano-systems smaller than 20 nm. In particular, through the estimation of the effective area, it allows to determine the local surface potential of single nanofiber as well as to simulate the KPFM image of nano-assemblies adsorbed both on electrically insulating and conducting substrates. This versatile model represents a useful tool to study with a high degree of precision the surface potential characteristics of nanowires paving the way towards their use as building blocks for the fabrication of electronic nanodevices with improved performance. |
Barboiu, Mihail ; Lehn, Jean-Marie Helical diastereomerism in self-organization of molecular strands Journal Article In: REVISTA DE CHIMIE, 59 (3), pp. 255–259, 2008, ISSN: 0034-7752. @article{barboiu_helical_2008, title = {Helical diastereomerism in self-organization of molecular strands}, author = {Barboiu, Mihail and Lehn, Jean-Marie}, issn = {0034-7752}, year = {2008}, date = {2008-03-01}, journal = {REVISTA DE CHIMIE}, volume = {59}, number = {3}, pages = {255--259}, abstract = {The polyheterocyclic molecule 2 reported in this paper is a helically-wrapped molecular strand presenting two helical substrands of same helicity separated in space thus forming P-P and M-M helical enantiomers. It represents the case of a molecule presenting two chiral centers of helical type. The dimerization process of the compound described in this paper appears to give rise to heterodimeric and homodimeric species. At high and room temperature the formation of dimeric species is accompanied by folding-unfolding interconversion of single molecular strands. Sliding of the monomers along one another without dissociation at low temperature allows each of two helical partners to associate in dimers stabilized by pronounced pi-pi stacking interactions between the internal heterocycles of the strands.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The polyheterocyclic molecule 2 reported in this paper is a helically-wrapped molecular strand presenting two helical substrands of same helicity separated in space thus forming P-P and M-M helical enantiomers. It represents the case of a molecule presenting two chiral centers of helical type. The dimerization process of the compound described in this paper appears to give rise to heterodimeric and homodimeric species. At high and room temperature the formation of dimeric species is accompanied by folding-unfolding interconversion of single molecular strands. Sliding of the monomers along one another without dissociation at low temperature allows each of two helical partners to associate in dimers stabilized by pronounced pi-pi stacking interactions between the internal heterocycles of the strands. |
Gerard, Davy ; Wenger, Jerome ; Bonod, Nicolas ; Popov, Evgeni ; Rigneault, Herve ; Mahdavi, Farhad ; Blair, Steve ; Dintinger, Jose ; Ebbesen, Thomas W Nanoaperture-enhanced fluorescence: Towards higher detection rates with plasmonic metals Journal Article In: PHYSICAL REVIEW B, 77 (4), 2008, ISSN: 1098-0121. @article{gerard_nanoaperture-enhanced_2008, title = {Nanoaperture-enhanced fluorescence: Towards higher detection rates with plasmonic metals}, author = {Gerard, Davy and Wenger, Jerome and Bonod, Nicolas and Popov, Evgeni and Rigneault, Herve and Mahdavi, Farhad and Blair, Steve and Dintinger, Jose and Ebbesen, Thomas W.}, doi = {10.1103/PhysRevB.77.045413}, issn = {1098-0121}, year = {2008}, date = {2008-01-01}, journal = {PHYSICAL REVIEW B}, volume = {77}, number = {4}, abstract = {A bare nanometric aperture milled in a metallic film forms a simple nanophotonic device that can strongly enhance the optical properties of nearby emitters such as fluorescent molecules. In this paper, we experimentally and numerically compare the properties of circular apertures milled in gold and aluminum, and discuss the influence of a noble metal holding plasmonic resonances in the visible range such as gold. We report that nanometric apertures milled in gold exhibit significantly higher fluorescence enhancement factors than apertures in aluminum. We relate this effect to a larger enhancement of the excitation intensity and radiative rate for an aperture milled in gold. A spectrally resolved analysis of the fluorescence emission from apertures is also presented. Comparison with numerical simulations shows that the enhancement factor is maximum when the photonic density of modes is maximum. Altogether, these results provide crucial knowledge for the design of nanoapertures towards high-efficiency single-molecule analysis.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A bare nanometric aperture milled in a metallic film forms a simple nanophotonic device that can strongly enhance the optical properties of nearby emitters such as fluorescent molecules. In this paper, we experimentally and numerically compare the properties of circular apertures milled in gold and aluminum, and discuss the influence of a noble metal holding plasmonic resonances in the visible range such as gold. We report that nanometric apertures milled in gold exhibit significantly higher fluorescence enhancement factors than apertures in aluminum. We relate this effect to a larger enhancement of the excitation intensity and radiative rate for an aperture milled in gold. A spectrally resolved analysis of the fluorescence emission from apertures is also presented. Comparison with numerical simulations shows that the enhancement factor is maximum when the photonic density of modes is maximum. Altogether, these results provide crucial knowledge for the design of nanoapertures towards high-efficiency single-molecule analysis. |
Volkov, V S; Bozhevolnyi, S I; Devaux, E; Laluet, J -Y; Ebbesen, T W Nanophotonic components utilizing channel plasmon polaritons Inproceedings In: {Kawata, S; Shalaev, VM ; Tsai, DP} (Ed.): PLASMONICS: NANOIMAGING, NANOFABRICATION, AND THEIR APPLICATIONS IV, SPIE, 2008, ISBN: 978-0-8194-7253-3. @inproceedings{volkov_nanophotonic_2008, title = {Nanophotonic components utilizing channel plasmon polaritons}, author = {Volkov, V. S. and Bozhevolnyi, S. I. and Devaux, E. and Laluet, J. -Y. and Ebbesen, T. W.}, editor = {{Kawata, S and Shalaev, VM and Tsai, DP}}, doi = {10.1117/12.794781}, isbn = {978-0-8194-7253-3}, year = {2008}, date = {2008-01-01}, booktitle = {PLASMONICS: NANOIMAGING, NANOFABRICATION, AND THEIR APPLICATIONS IV}, volume = {7033}, publisher = {SPIE}, series = {Proceedings of SPIE}, abstract = {Channel plasmon polaritons (CPPs) propagating along the bottom of subwavelength grooves cut into a metal surface were recently shown to exhibit strong confinement combined with low propagation loss, a feature that makes this guiding configuration very promising for the realisation of ultra-compact photonic components. Here, the results of Our investigations of CPP guiding by V-grooves cut into gold are presented, demonstrating efficient large-angle bending and splitting of radiation as well as waveguide-ring resonators and Bragg grating filters.}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } Channel plasmon polaritons (CPPs) propagating along the bottom of subwavelength grooves cut into a metal surface were recently shown to exhibit strong confinement combined with low propagation loss, a feature that makes this guiding configuration very promising for the realisation of ultra-compact photonic components. Here, the results of Our investigations of CPP guiding by V-grooves cut into gold are presented, demonstrating efficient large-angle bending and splitting of radiation as well as waveguide-ring resonators and Bragg grating filters. |
Pu, Jingzhi ; Karplus, Martin How subunit coupling produces the gamma-subunit rotary motion in F-1-ATPase Journal Article In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 (4), pp. 1192–1197, 2008, ISSN: 0027-8424. @article{pu_how_2008, title = {How subunit coupling produces the gamma-subunit rotary motion in F-1-ATPase}, author = {Pu, Jingzhi and Karplus, Martin}, doi = {10.1073/pnas.0708746105}, issn = {0027-8424}, year = {2008}, date = {2008-01-01}, journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, volume = {105}, number = {4}, pages = {1192--1197}, abstract = {F0F1-ATP synthase manufactures the energy “currency,” ATP, of living cells. The soluble F, portion, called F-1-ATPase, can act as a rotary motor, with ATP binding, hydrolysis, and product release, inducing a torque on the gamma-subunit. A coarse-grained plastic network model is used to show at a residue level of detail how the conformational changes of the catalytic beta-subunits act on the gamma-subunit through repulsive van der Waals interactions to generate a torque that drives unidirectional rotation, as observed experimentally. The simulations suggest that the calculated 85 degrees substep rotation is driven primarily by ATP binding and that the subsequent 35 degrees substep rotation is produced by product release from one beta-subunit and a concomitant binding pocket expansion of another beta-subunit. The results of the simulation agree with single-molecule experiments [see, for example, Adachi K, et al. (2007) Cell 130:3093211 and support a tri-site rotary mechanism for F-1-ATPase under physiological condition.}, keywords = {}, pubstate = {published}, tppubtype = {article} } F0F1-ATP synthase manufactures the energy “currency,” ATP, of living cells. The soluble F, portion, called F-1-ATPase, can act as a rotary motor, with ATP binding, hydrolysis, and product release, inducing a torque on the gamma-subunit. A coarse-grained plastic network model is used to show at a residue level of detail how the conformational changes of the catalytic beta-subunits act on the gamma-subunit through repulsive van der Waals interactions to generate a torque that drives unidirectional rotation, as observed experimentally. The simulations suggest that the calculated 85 degrees substep rotation is driven primarily by ATP binding and that the subsequent 35 degrees substep rotation is produced by product release from one beta-subunit and a concomitant binding pocket expansion of another beta-subunit. The results of the simulation agree with single-molecule experiments [see, for example, Adachi K, et al. (2007) Cell 130:3093211 and support a tri-site rotary mechanism for F-1-ATPase under physiological condition. |
Chekmarev, Sergei F; Palyanov, Andrey Yu. ; Karplus, Martin Hydrodynamic description of protein folding Journal Article In: PHYSICAL REVIEW LETTERS, 100 (1), 2008, ISSN: 0031-9007. @article{chekmarev_hydrodynamic_2008, title = {Hydrodynamic description of protein folding}, author = {Chekmarev, Sergei F. and Palyanov, Andrey Yu. and Karplus, Martin}, doi = {10.1103/PhysRevLett.100.018107}, issn = {0031-9007}, year = {2008}, date = {2008-01-01}, journal = {PHYSICAL REVIEW LETTERS}, volume = {100}, number = {1}, abstract = {A hydrodynamic description of protein folding is proposed and illustrated with a lattice protein model, which has a free energy surface (FES) typical of proteins with two-state folding kinetics. The flows from the unfolded to the native state are concentrated in a limited region of the FES. The rest is occupied by a flow “vortex”, which does not lead to the native state. In contrast with intermediates that are associated with local minima, the vortex is not visible on the FES. The hydrodynamic interpretation thus provides new insights into the mechanism of protein folding and can be a useful complement to standard analyses.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A hydrodynamic description of protein folding is proposed and illustrated with a lattice protein model, which has a free energy surface (FES) typical of proteins with two-state folding kinetics. The flows from the unfolded to the native state are concentrated in a limited region of the FES. The rest is occupied by a flow “vortex”, which does not lead to the native state. In contrast with intermediates that are associated with local minima, the vortex is not visible on the FES. The hydrodynamic interpretation thus provides new insights into the mechanism of protein folding and can be a useful complement to standard analyses. |
Hwang, Wonmuk ; Lang, Matthew J; Karplus, Martin Force generation in kinesin hinges on cover-neck bundle formation Journal Article In: STRUCTURE, 16 (1), pp. 62–71, 2008, ISSN: 0969-2126. @article{hwang_force_2008, title = {Force generation in kinesin hinges on cover-neck bundle formation}, author = {Hwang, Wonmuk and Lang, Matthew J. and Karplus, Martin}, doi = {10.1016/j.str.2007.11.008}, issn = {0969-2126}, year = {2008}, date = {2008-01-01}, journal = {STRUCTURE}, volume = {16}, number = {1}, pages = {62--71}, abstract = {In kinesin motors, a fundamental question concerns the mechanism by which ATP binding generates the force required for walking. Analysis of available structures combined with molecular dynamics simulations demonstrates that the conformational change of the neck linker involves the nine-residue-long N-terminal region, the cover strand, as an element that is essential for force generation. Upon ATP binding, it forms a beta sheet with the neck linker, the cover-neck bundle, which induces the forward motion of the neck linker, followed by a latch-type binding to the motor head. The estimated stall force and anisotropic response to external loads calculated from the model agree with force-clamp measurements. The proposed mechanism for force generation by the cover-neck bundle formation appears to apply to several kinesin families. It also elucidates the design principle of kinesin as the smallest known processive motor.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In kinesin motors, a fundamental question concerns the mechanism by which ATP binding generates the force required for walking. Analysis of available structures combined with molecular dynamics simulations demonstrates that the conformational change of the neck linker involves the nine-residue-long N-terminal region, the cover strand, as an element that is essential for force generation. Upon ATP binding, it forms a beta sheet with the neck linker, the cover-neck bundle, which induces the forward motion of the neck linker, followed by a latch-type binding to the motor head. The estimated stall force and anisotropic response to external loads calculated from the model agree with force-clamp measurements. The proposed mechanism for force generation by the cover-neck bundle formation appears to apply to several kinesin families. It also elucidates the design principle of kinesin as the smallest known processive motor. |
Liscio, Andrea ; De Luca, Giovanna ; Nolde, Fabian ; Palermo, Vincenzo ; Muellen, Klaus ; Samori, Paolo Photovoltaic charge generation visualized at the nanoscale: A proof of principle Journal Article In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (3), pp. 780+, 2008, ISSN: 0002-7863. @article{liscio_photovoltaic_2008, title = {Photovoltaic charge generation visualized at the nanoscale: A proof of principle}, author = {Liscio, Andrea and De Luca, Giovanna and Nolde, Fabian and Palermo, Vincenzo and Muellen, Klaus and Samori, Paolo}, doi = {10.1021/ja075291r}, issn = {0002-7863}, year = {2008}, date = {2008-01-01}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, volume = {130}, number = {3}, pages = {780+}, abstract = {We report for the first time a nanoscale resolved proof of principle of the photovoltaic activity in phase-segregated electron acceptor-donor blend architectures as obtained by Kelvin probe force microscopy. The explored length scale is truly important for organic solar cells since it is comparable to the mean exciton diffusion length. We chose a blend of regioregular poly(3-hexylthiophene) (P3HT) and N,N-bis(1-ethylpropyl)-3,4:9,10- perylenebisdicarboximide) (PDI) as model systems, acting as electron donor and electron. acceptor, respectively. In this work, we demonstrate that the same type of molecular assemblies, obtained from a given electron-accepting material on the same sample, shows different surface potential changes upon white-light illumination when in physical contact with the donor materials or isolated from it. Although excitons are generated by light absorption in all the PDI clusters, we unambiguously proved that only the ones which are in physical contact with P3HT exhibit an appreciable charge transfer because of the existence of a complementary electron donor phase. Such a direct observation is novel and of general applicability and can also be extended to other bicomponent materials for plastic photovoltaics.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We report for the first time a nanoscale resolved proof of principle of the photovoltaic activity in phase-segregated electron acceptor-donor blend architectures as obtained by Kelvin probe force microscopy. The explored length scale is truly important for organic solar cells since it is comparable to the mean exciton diffusion length. We chose a blend of regioregular poly(3-hexylthiophene) (P3HT) and N,N-bis(1-ethylpropyl)-3,4:9,10- perylenebisdicarboximide) (PDI) as model systems, acting as electron donor and electron. acceptor, respectively. In this work, we demonstrate that the same type of molecular assemblies, obtained from a given electron-accepting material on the same sample, shows different surface potential changes upon white-light illumination when in physical contact with the donor materials or isolated from it. Although excitons are generated by light absorption in all the PDI clusters, we unambiguously proved that only the ones which are in physical contact with P3HT exhibit an appreciable charge transfer because of the existence of a complementary electron donor phase. Such a direct observation is novel and of general applicability and can also be extended to other bicomponent materials for plastic photovoltaics. |
Pace, Giuseppina ; Petitjean, Anne ; Lalloz-Vogel, Marie-Noelle ; Harrowfield, Jack ; Lehn, Jean-Marie ; Samori, Paolo Subnanometer-resolved patterning of bicomponent self-assembled monolayers on Au(111) Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (13), pp. 2484–2488, 2008, ISSN: 1433-7851. @article{pace_subnanometer-resolved_2008, title = {Subnanometer-resolved patterning of bicomponent self-assembled monolayers on Au(111)}, author = {Pace, Giuseppina and Petitjean, Anne and Lalloz-Vogel, Marie-Noelle and Harrowfield, Jack and Lehn, Jean-Marie and Samori, Paolo}, doi = {10.1002/anie.200704731}, issn = {1433-7851}, year = {2008}, date = {2008-01-01}, journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, volume = {47}, number = {13}, pages = {2484--2488}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Ferri, Violetta ; Elbing, Mark ; Pace, Giuseppina ; Dickey, Michael D; Zharnikov, Michael ; Samori, Paolo ; Mayor, Marcel ; Rampi, Maria Anita Light-powered electrical switch based on cargo-lifting azobenzene monolayers Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (18), pp. 3407–3409, 2008, ISSN: 1433-7851. @article{ferri_light-powered_2008, title = {Light-powered electrical switch based on cargo-lifting azobenzene monolayers}, author = {Ferri, Violetta and Elbing, Mark and Pace, Giuseppina and Dickey, Michael D. and Zharnikov, Michael and Samori, Paolo and Mayor, Marcel and Rampi, Maria Anita}, doi = {10.1002/anie.200705339}, issn = {1433-7851}, year = {2008}, date = {2008-01-01}, journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, volume = {47}, number = {18}, pages = {3407--3409}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Palma, Carlos-Andres ; Bonini, Massimo ; Llanes-Pallas, Anna ; Breiner, Thomas ; Prato, Maurizio ; Bonifazi, Davide ; Samori, Paolo Pre-programmed bicomponent porous networks at the solid-liquid interface: the low concentration regime Journal Article In: CHEMICAL COMMUNICATIONS, (42), pp. 5289–5291, 2008, ISSN: 1359-7345. @article{palma_pre-programmed_2008, title = {Pre-programmed bicomponent porous networks at the solid-liquid interface: the low concentration regime}, author = {Palma, Carlos-Andres and Bonini, Massimo and Llanes-Pallas, Anna and Breiner, Thomas and Prato, Maurizio and Bonifazi, Davide and Samori, Paolo}, doi = {10.1039/b811534f}, issn = {1359-7345}, year = {2008}, date = {2008-01-01}, journal = {CHEMICAL COMMUNICATIONS}, number = {42}, pages = {5289--5291}, abstract = {The control over the formation of a bicomponent porous network was attained by self-assembly at the solid-liquid interface, exploiting triple H-bonds between melamine and bis-uracyl modules.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The control over the formation of a bicomponent porous network was attained by self-assembly at the solid-liquid interface, exploiting triple H-bonds between melamine and bis-uracyl modules. |
Palma, Matteo ; Levin, Jeremy ; Debever, Olivier ; Geerts, Yves ; Lehmann, Matthias ; Samori, Paolo Self-assembly of hydrogen-bond assisted supramolecular azatriphenylene architectures Journal Article In: SOFT MATTER, 4 (2), pp. 303–310, 2008, ISSN: 1744-683X. @article{palma_self-assembly_2008, title = {Self-assembly of hydrogen-bond assisted supramolecular azatriphenylene architectures}, author = {Palma, Matteo and Levin, Jeremy and Debever, Olivier and Geerts, Yves and Lehmann, Matthias and Samori, Paolo}, doi = {10.1039/b713570j}, issn = {1744-683X}, year = {2008}, date = {2008-01-01}, journal = {SOFT MATTER}, volume = {4}, number = {2}, pages = {303--310}, abstract = {We report on the self-assembly of a functionalized hexaazatriphenylene into supramolecular architectures where the single hexaazatriphenylene molecules are held together primarily through intermolecular hydrogen bonds between amide units. Wide and small angle X-ray scattering, polarized light microscopy, and differential scanning calorimetry revealed bulk self-organization into columnar structures. At the surfaces, scanning force microscopy experiments showed that it is possible to drive the self-organization from solutions of N-(2-ethylhexyl)-hexacarboxamidohexaazatriphenylene, towards either layers on a conductive surface like graphite or supramolecular anisotropic assemblies on an electrically insulating substrate such as muscovite mica. The growth of this latter type of architecture is primarily driven by the physical dewetting of the solution cast on the surface combined with intermolecular hydrogen bonds between the amide moieties exposed in the peripheral positions that lead to the formation of the columnar stack. Therefore, the anisotropic supramolecular azatriphenylene assemblies observed in the bulk have been also observed in thin films on a substrate poorly interacting with the adsorbate. In view of the interesting electronic properties of hexaazatriphenylene based architectures as n-type semiconductors, these results might be of interest for applications in the field of organic electronics.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We report on the self-assembly of a functionalized hexaazatriphenylene into supramolecular architectures where the single hexaazatriphenylene molecules are held together primarily through intermolecular hydrogen bonds between amide units. Wide and small angle X-ray scattering, polarized light microscopy, and differential scanning calorimetry revealed bulk self-organization into columnar structures. At the surfaces, scanning force microscopy experiments showed that it is possible to drive the self-organization from solutions of N-(2-ethylhexyl)-hexacarboxamidohexaazatriphenylene, towards either layers on a conductive surface like graphite or supramolecular anisotropic assemblies on an electrically insulating substrate such as muscovite mica. The growth of this latter type of architecture is primarily driven by the physical dewetting of the solution cast on the surface combined with intermolecular hydrogen bonds between the amide moieties exposed in the peripheral positions that lead to the formation of the columnar stack. Therefore, the anisotropic supramolecular azatriphenylene assemblies observed in the bulk have been also observed in thin films on a substrate poorly interacting with the adsorbate. In view of the interesting electronic properties of hexaazatriphenylene based architectures as n-type semiconductors, these results might be of interest for applications in the field of organic electronics. |
De Luca, Giovanna ; Liscio, Andrea ; Nolde, Fabian ; Scolaro, Luigi Monsu ; Palermo, Vincenzo ; Muellen, Klaus ; Samori, Paolo Self-assembly of discotic molecules into mesoscopic crystals by solvent-vapour annealing Journal Article In: SOFT MATTER, 4 (10), pp. 2064–2070, 2008, ISSN: 1744-683X. @article{de_luca_self-assembly_2008, title = {Self-assembly of discotic molecules into mesoscopic crystals by solvent-vapour annealing}, author = {De Luca, Giovanna and Liscio, Andrea and Nolde, Fabian and Scolaro, Luigi Monsu and Palermo, Vincenzo and Muellen, Klaus and Samori, Paolo}, doi = {10.1039/b807391k}, issn = {1744-683X}, year = {2008}, date = {2008-01-01}, journal = {SOFT MATTER}, volume = {4}, number = {10}, pages = {2064--2070}, abstract = {Solvent vapour annealing (SVA) is used to control the reorganization of ultrathin films of three different polycyclic aromatic hydrocarbons self-assembled on solid surfaces. To this end, two perylene-bis( dicarboximide) (PDI) derivatives exposing branched side alkyl chains with different length and a dodecyl substituted hexa-peri-hexabenzocoronene (HBC) have been used, in view of their n- and p-type semiconducting nature. For all the three molecules, nanoscopic crystals grown from solution by spin-coating and drop-casting undergo reorganization into sub-millimetric fibers, domes and needles, proving the general applicability of the SVA method. Moreover, such an approach exhibits a mass transport of the molecules on surfaces over hundreds of microns. The self-healing of the films through SVA treatment leads to a decrease of the structural defects and an increase in the lateral size of the self-assembled domains, ultimately providing an improved 3D conjugation. Therefore the SVA can be considered an important strategy with potential to enhance the performance of macroscopic organic electronic devices.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Solvent vapour annealing (SVA) is used to control the reorganization of ultrathin films of three different polycyclic aromatic hydrocarbons self-assembled on solid surfaces. To this end, two perylene-bis( dicarboximide) (PDI) derivatives exposing branched side alkyl chains with different length and a dodecyl substituted hexa-peri-hexabenzocoronene (HBC) have been used, in view of their n- and p-type semiconducting nature. For all the three molecules, nanoscopic crystals grown from solution by spin-coating and drop-casting undergo reorganization into sub-millimetric fibers, domes and needles, proving the general applicability of the SVA method. Moreover, such an approach exhibits a mass transport of the molecules on surfaces over hundreds of microns. The self-healing of the films through SVA treatment leads to a decrease of the structural defects and an increase in the lateral size of the self-assembled domains, ultimately providing an improved 3D conjugation. Therefore the SVA can be considered an important strategy with potential to enhance the performance of macroscopic organic electronic devices. |
Mativetsky, Jeffrey A; Palma, Matteo ; Samori, Paolo Exploring electronic transport in molecular junctions by conducting atomic force microscopy Incollection In: {Samori, P} (Ed.): STM AND AFM STUDIES ON (BIO)MOLECULAR SYSTEMS: UNRAVELLING THE NANOWORLD, 285 , pp. 157–202, 2008, ISBN: 978-3-540-78394-7. @incollection{mativetsky_exploring_2008, title = {Exploring electronic transport in molecular junctions by conducting atomic force microscopy}, author = {Mativetsky, Jeffrey A. and Palma, Matteo and Samori, Paolo}, editor = {{Samori, P}}, doi = {10.1007/128_2007_25}, isbn = {978-3-540-78394-7}, year = {2008}, date = {2008-01-01}, booktitle = {STM AND AFM STUDIES ON (BIO)MOLECULAR SYSTEMS: UNRAVELLING THE NANOWORLD}, volume = {285}, pages = {157--202}, series = {Topics in Current Chemistry-Series}, abstract = {Measuring the electronic transport properties of single molecules and molecular nanostructures is an interesting and challenging new frontier from both a fundamental as well as technological perspective. Conducting atomic force microscopy (C-AFM) represents an attractive line of approach given its ability to position a sharp electrical probe with nanometer-scale precision and a controlled nano-Newton-range force. Moreover, the combination of AFM imaging and C-AFM electrical characterization enables investigation of the relationship between structure and function in molecular architectures. The aim of the present review is twofold: (1) to introduce the C-AFM method, alongside a discussion of experimental practices, capabilities and limitations, and (2) to provide an overview of the application of C-AFM to different types of molecular systems. These include alkane-based and oligomer-based self-assembled monolayers, molecular crystals, conducting polymer films, molecular wires (e.g. carbon nanotubes), and electrically active biomolecules. We will also discuss C-AFM approaches that allow single molecule measurements as well as other recent developments.}, keywords = {}, pubstate = {published}, tppubtype = {incollection} } Measuring the electronic transport properties of single molecules and molecular nanostructures is an interesting and challenging new frontier from both a fundamental as well as technological perspective. Conducting atomic force microscopy (C-AFM) represents an attractive line of approach given its ability to position a sharp electrical probe with nanometer-scale precision and a controlled nano-Newton-range force. Moreover, the combination of AFM imaging and C-AFM electrical characterization enables investigation of the relationship between structure and function in molecular architectures. The aim of the present review is twofold: (1) to introduce the C-AFM method, alongside a discussion of experimental practices, capabilities and limitations, and (2) to provide an overview of the application of C-AFM to different types of molecular systems. These include alkane-based and oligomer-based self-assembled monolayers, molecular crystals, conducting polymer films, molecular wires (e.g. carbon nanotubes), and electrically active biomolecules. We will also discuss C-AFM approaches that allow single molecule measurements as well as other recent developments. |
Giuseppone, Nicolas ; Schmitt, Jean-Louis ; Allouche, Lionel ; Lehn, Jean-Marie DOSY NMR experiments as a tool for the analysis of constitutional and motional dynamic processes: Implementation for the driven evolution of dynamic combinatorial libraries of helical strands Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (12), pp. 2235–2239, 2008, ISSN: 1433-7851. @article{giuseppone_dosy_2008, title = {DOSY NMR experiments as a tool for the analysis of constitutional and motional dynamic processes: Implementation for the driven evolution of dynamic combinatorial libraries of helical strands}, author = {Giuseppone, Nicolas and Schmitt, Jean-Louis and Allouche, Lionel and Lehn, Jean-Marie}, doi = {10.1002/anie.200703168}, issn = {1433-7851}, year = {2008}, date = {2008-01-01}, journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, volume = {47}, number = {12}, pages = {2235--2239}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Ruff, Yves ; Lehn, Jean-Marie Glycodynamers: Fluorescent dynamic analogues of polysaccharides Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (19), pp. 3556–3559, 2008, ISSN: 1433-7851. @article{ruff_glycodynamers:_2008-1, title = {Glycodynamers: Fluorescent dynamic analogues of polysaccharides}, author = {Ruff, Yves and Lehn, Jean-Marie}, doi = {10.1002/anie.200703490}, issn = {1433-7851}, year = {2008}, date = {2008-01-01}, journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, volume = {47}, number = {19}, pages = {3556--3559}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Lehn, Jean-Marie A Jubilee 60th Congress of the Association of Czech and Slovak chemical company. Olomouc, 1st-4th September 2008 - Abstracts Journal Article In: CHEMICKE LISTY, 102 (8), pp. 595–759, 2008, ISSN: 0009-2770. @article{lehn_jubilee_2008, title = {A Jubilee 60th Congress of the Association of Czech and Slovak chemical company. Olomouc, 1st-4th September 2008 - Abstracts}, author = {Lehn, Jean-Marie}, issn = {0009-2770}, year = {2008}, date = {2008-01-01}, journal = {CHEMICKE LISTY}, volume = {102}, number = {8}, pages = {595--759}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Sreenivasachary, Nampally ; Lehn, Jean-Marie Structural selection in G-quartet-based hydrogels and controlled release of bioactive molecules Journal Article In: CHEMISTRY-AN ASIAN JOURNAL, 3 (1), pp. 134–139, 2008, ISSN: 1861-4728. @article{sreenivasachary_structural_2008, title = {Structural selection in G-quartet-based hydrogels and controlled release of bioactive molecules}, author = {Sreenivasachary, Nampally and Lehn, Jean-Marie}, doi = {10.1002/asia.200700041}, issn = {1861-4728}, year = {2008}, date = {2008-01-01}, journal = {CHEMISTRY-AN ASIAN JOURNAL}, volume = {3}, number = {1}, pages = {134--139}, abstract = {A guanosine-5'-hydrazide can entrap biologically interesting molecules such as acyclovir, vitamin C, and vancomycin into its hydrogel network. Controlled release of these molecules was monitored by H-1 NMR spectroscopy. The hydrazide may potentially form mixed G-G quartets with analogous compounds containing a guanine Group. H-1 NMR spectroscopy was used to study the inclusion of various guanine derivatives into the hydrogel. The structural selectivity was found to depend strongly on both the shape and the charge of the additive and may arise from the strong cohesion of the supramolecular architecture of the gel and the resulting resistance to perturbation by foreign bodies. Hydrogels thus offer a promising medium for highly selective, controlled release of bioactive substances.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A guanosine-5'-hydrazide can entrap biologically interesting molecules such as acyclovir, vitamin C, and vancomycin into its hydrogel network. Controlled release of these molecules was monitored by H-1 NMR spectroscopy. The hydrazide may potentially form mixed G-G quartets with analogous compounds containing a guanine Group. H-1 NMR spectroscopy was used to study the inclusion of various guanine derivatives into the hydrogel. The structural selectivity was found to depend strongly on both the shape and the charge of the additive and may arise from the strong cohesion of the supramolecular architecture of the gel and the resulting resistance to perturbation by foreign bodies. Hydrogels thus offer a promising medium for highly selective, controlled release of bioactive substances. |
Chow, Cheuk-Fai ; Fujii, Shunsuke ; Lehn, Jean-Marie Metallodynamers: Neutral double-dynamic metallosupramolecular polymers Journal Article In: CHEMISTRY-AN ASIAN JOURNAL, 3 (8-9), pp. 1324–1335, 2008, ISSN: 1861-4728. @article{chow_metallodynamers:_2008, title = {Metallodynamers: Neutral double-dynamic metallosupramolecular polymers}, author = {Chow, Cheuk-Fai and Fujii, Shunsuke and Lehn, Jean-Marie}, doi = {10.1002/asia.200800101}, issn = {1861-4728}, year = {2008}, date = {2008-01-01}, journal = {CHEMISTRY-AN ASIAN JOURNAL}, volume = {3}, number = {8-9}, pages = {1324--1335}, abstract = {Nine neutral dynamic metallosupramolecular polymers (metallodynamers) based on acyl hydrazone derived metal coordination centers (Co2+, Ni2+, Zn2+, and Cd2+) were generated through self-assembly polymerization. These are linear coordination polymers with specific optical and mechanical properties. Monomer selection was found to take place in a mixture of subcomponents (carboxyaldehydes and bisacyl hydrazides) driven by hexacoordination to a specific metal ion. Most importantly, the metallodynamers were found to modify their constitution by exchanging and reshuffling their components with another metallodynamer through ligand exchange at the metal coordination site in solution as well as in the neat phase. As a result, the materials undergo remarkable changes in both their mechanical and optical properties.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Nine neutral dynamic metallosupramolecular polymers (metallodynamers) based on acyl hydrazone derived metal coordination centers (Co2+, Ni2+, Zn2+, and Cd2+) were generated through self-assembly polymerization. These are linear coordination polymers with specific optical and mechanical properties. Monomer selection was found to take place in a mixture of subcomponents (carboxyaldehydes and bisacyl hydrazides) driven by hexacoordination to a specific metal ion. Most importantly, the metallodynamers were found to modify their constitution by exchanging and reshuffling their components with another metallodynamer through ligand exchange at the metal coordination site in solution as well as in the neat phase. As a result, the materials undergo remarkable changes in both their mechanical and optical properties. |
Hickman, David T; Sreenivasachary, Nampally ; Lehn, Jean-Marie Synthesis of components for the generation of constitutional dynamic analogues of nucleic acids Journal Article In: HELVETICA CHIMICA ACTA, 91 (1), pp. 1–20, 2008, ISSN: 0018-019X. @article{hickman_synthesis_2008, title = {Synthesis of components for the generation of constitutional dynamic analogues of nucleic acids}, author = {Hickman, David T. and Sreenivasachary, Nampally and Lehn, Jean-Marie}, doi = {10.1002/hlca.200890022}, issn = {0018-019X}, year = {2008}, date = {2008-01-01}, journal = {HELVETICA CHIMICA ACTA}, volume = {91}, number = {1}, pages = {1--20}, abstract = {The introduction of dynamic covalent polymers, in which the monomer units are linked by reversible covalent bonds and can undergo component exchange, opens up new possibilities for the generation of functional materials. Extending this approach to the generation of dynamic biopolymers in aqueous media, which are able to adapt constitution (sequence, length) to external factors (e.g., environment, medium, template), would provide an alternative approach to the de novo design of functional dynamic bio-macromolecules. As a first step towards this goal, various mono- and bifunctionalised (hetero- and homotopic) nucleic acid-derived building blocks of type I-X have been synthesised for the generation of dynamic main-chain and side-chain reversible nucleic acid analogues. Hydrazide- and/or acetal (protected carbonyl)-functionalised components were selected, which differ in terms of flexibility, length, net formal charge, and hydrazide/acetal substituents, in order to explore how such factors may affect the properties (structure, solubility, molecular recognition features) of the polymer products that may be generated by polycondensation.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The introduction of dynamic covalent polymers, in which the monomer units are linked by reversible covalent bonds and can undergo component exchange, opens up new possibilities for the generation of functional materials. Extending this approach to the generation of dynamic biopolymers in aqueous media, which are able to adapt constitution (sequence, length) to external factors (e.g., environment, medium, template), would provide an alternative approach to the de novo design of functional dynamic bio-macromolecules. As a first step towards this goal, various mono- and bifunctionalised (hetero- and homotopic) nucleic acid-derived building blocks of type I-X have been synthesised for the generation of dynamic main-chain and side-chain reversible nucleic acid analogues. Hydrazide- and/or acetal (protected carbonyl)-functionalised components were selected, which differ in terms of flexibility, length, net formal charge, and hydrazide/acetal substituents, in order to explore how such factors may affect the properties (structure, solubility, molecular recognition features) of the polymer products that may be generated by polycondensation. |
Barluenga, Sofia ; Wang, Cuihua ; Fontaine, Jean-Gonzague ; Aouadi, Kaiss ; Beebe, Kristin ; Tsutsumi, Shinji ; Neckers, Len ; Winssinger, Nicolas Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (23), pp. 4432–4435, 2008, ISSN: 1433-7851. @article{barluenga_divergent_2008, title = {Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor}, author = {Barluenga, Sofia and Wang, Cuihua and Fontaine, Jean-Gonzague and Aouadi, Kaiss and Beebe, Kristin and Tsutsumi, Shinji and Neckers, Len and Winssinger, Nicolas}, doi = {10.1002/anie.200800233}, issn = {1433-7851}, year = {2008}, date = {2008-01-01}, journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, volume = {47}, number = {23}, pages = {4432--4435}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garcia-Cuadrado, Domingo ; Barluenga, Sofia ; Winssinger, Nicolas Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents Journal Article In: CHEMICAL COMMUNICATIONS, (38), pp. 4619–4621, 2008, ISSN: 1359-7345. @article{garcia-cuadrado_diversity-oriented_2008, title = {Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents}, author = {Garcia-Cuadrado, Domingo and Barluenga, Sofia and Winssinger, Nicolas}, doi = {10.1039/b807869f}, issn = {1359-7345}, year = {2008}, date = {2008-01-01}, journal = {CHEMICAL COMMUNICATIONS}, number = {38}, pages = {4619--4621}, abstract = {A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity. |
Pianowski, Zbigniew L; Winssinger, Nicolas Nucleic acid encoding to program self-assembly in chemical biology Journal Article In: CHEMICAL SOCIETY REVIEWS, 37 (7), pp. 1330–1336, 2008, ISSN: 0306-0012. @article{pianowski_nucleic_2008, title = {Nucleic acid encoding to program self-assembly in chemical biology}, author = {Pianowski, Zbigniew L. and Winssinger, Nicolas}, doi = {10.1039/b706610b}, issn = {0306-0012}, year = {2008}, date = {2008-01-01}, journal = {CHEMICAL SOCIETY REVIEWS}, volume = {37}, number = {7}, pages = {1330--1336}, abstract = {This tutorial review serves as an introduction to the use of oligonucleotides and in particular peptide nucleic acids (PNAs) to encode function beyond heredity. Applications in chemical biology are reviewed starting with the use of nucleic acid tags to program self-assembled microarrays of small and macromolecules, followed by the use of nucleic acid templated reactions for the purpose of DNA or RNA sensing and finally, the use of nucleic acid templates to display ligands.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This tutorial review serves as an introduction to the use of oligonucleotides and in particular peptide nucleic acids (PNAs) to encode function beyond heredity. Applications in chemical biology are reviewed starting with the use of nucleic acid tags to program self-assembled microarrays of small and macromolecules, followed by the use of nucleic acid templated reactions for the purpose of DNA or RNA sensing and finally, the use of nucleic acid templates to display ligands. |
Prikhod'ko, Alexander I; Durola, Fabien ; Sauvage, Jean-Pierre Iron(II)-templated synthesis of [3]rotaxanes by passing two threads through the same ring Journal Article In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (2), pp. 448+, 2008, ISSN: 0002-7863. @article{prikhodko_ironii-templated_2008, title = {Iron(II)-templated synthesis of [3]rotaxanes by passing two threads through the same ring}, author = {Prikhod'ko, Alexander I. and Durola, Fabien and Sauvage, Jean-Pierre}, doi = {10.1021/ja078216p}, issn = {0002-7863}, year = {2008}, date = {2008-01-01}, journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, volume = {130}, number = {2}, pages = {448+}, abstract = {The three-dimensional template effect of an octahedral iron(II) center has been exploited for threading two coordinating molecular units, each one is a bidentate 3.3'-biisoquinoline ligand bearing p-anisyl groups, through a coordinating 41-membered macrocycle containing the same endocyclic but nonstreically hindering chelate. The double threading process is driven by coordination of three bidentate ligands to the iron(II) center. By replacing the threads decorated with p-anisyl substituents by analogous long-chain ligands bearing appropriate end-functions (azide), the double threading process is as efficient as with the shorter (p-anisyl) chelates. An efficient quadruple end-functionalization reaction based on the copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (”click” chemistry) affords the desired iron(II)-complexed two-string [3]rotaxane in excellent yield.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The three-dimensional template effect of an octahedral iron(II) center has been exploited for threading two coordinating molecular units, each one is a bidentate 3.3'-biisoquinoline ligand bearing p-anisyl groups, through a coordinating 41-membered macrocycle containing the same endocyclic but nonstreically hindering chelate. The double threading process is driven by coordination of three bidentate ligands to the iron(II) center. By replacing the threads decorated with p-anisyl substituents by analogous long-chain ligands bearing appropriate end-functions (azide), the double threading process is as efficient as with the shorter (p-anisyl) chelates. An efficient quadruple end-functionalization reaction based on the copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (”click” chemistry) affords the desired iron(II)-complexed two-string [3]rotaxane in excellent yield. |
Beyler, Maryline ; Heitz, Valerie ; Sauvage, Jean-Pierre Quantitative formation of a tetraporphyrin [2] catenane via copper and zinc coordination Journal Article In: CHEMICAL COMMUNICATIONS, (42), pp. 5396–5398, 2008, ISSN: 1359-7345. @article{beyler_quantitative_2008, title = {Quantitative formation of a tetraporphyrin [2] catenane via copper and zinc coordination}, author = {Beyler, Maryline and Heitz, Valerie and Sauvage, Jean-Pierre}, doi = {10.1039/b811013a}, issn = {1359-7345}, year = {2008}, date = {2008-01-01}, journal = {CHEMICAL COMMUNICATIONS}, number = {42}, pages = {5396--5398}, abstract = {A [2] catenane is formed quantitatively by mixing substituted 1,10-phenanthroline- based chelates with copper(I) acting as central template, the ring- forming reaction being based on 1the coordination of pyridinic bidentate ligands onto the zinc atoms of the four porphyrins surrounding the core of the molecule.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A [2] catenane is formed quantitatively by mixing substituted 1,10-phenanthroline- based chelates with copper(I) acting as central template, the ring- forming reaction being based on 1the coordination of pyridinic bidentate ligands onto the zinc atoms of the four porphyrins surrounding the core of the molecule. |
Ventura, Barbara ; Barigelletti, Francesco ; Durola, Fabien ; Flamigni, Lucia ; Sauvage, Jean-Pierre ; Wenger, Oliver S Fe(II), Ru(II) and Re(I) complexes of endotopic, sterically non-hindering, U-shaped 8,8'-disubstituted-3,3'-biisoquinoline ligands: syntheses and spectroscopic properties Journal Article In: DALTON TRANSACTIONS, (4), pp. 491–498, 2008, ISSN: 1477-9226. @article{ventura_feii_2008, title = {Fe(II), Ru(II) and Re(I) complexes of endotopic, sterically non-hindering, U-shaped 8,8'-disubstituted-3,3'-biisoquinoline ligands: syntheses and spectroscopic properties}, author = {Ventura, Barbara and Barigelletti, Francesco and Durola, Fabien and Flamigni, Lucia and Sauvage, Jean-Pierre and Wenger, Oliver S.}, doi = {10.1039/b712834g}, issn = {1477-9226}, year = {2008}, date = {2008-01-01}, journal = {DALTON TRANSACTIONS}, number = {4}, pages = {491--498}, abstract = {The redox behaviour, optical-absorption spectra and emission properties of U-shaped and elongated disubstituted biisoquinoline ligands and of derived octahedral Fe(II), Ru(II), and Re(I) complexes are reported. The ligands are 8,8'-dichloro-3,3'-biisoquinoline (1), 8,8'-dianisyl-3,3'-biisoquinoline (2), and 8,8'-di(phenylanisyl)-3,3'-biisoquinoline (3), and the complexes are [Fe(2)(3)](2+), [Fe(3)(3)](2+), [Ru(1)(phen)(2)](2+), [Ru(2)(3)](2+), [Ru(3)(3)](2+), [Re(2)(py)(CO)(3)](+), and [Re(3)(py)(CO)(3)](+). For the ligands, the optical properties as observed in dichloromethane are in line with expectations based on the predominant (1)pi pi* nature of the involved excited states, with contributions at lower energies from (1)n pi* and (ILCT)-I-1 (intraligand charge transfer) transitions. For all of the Fe(II), Ru(II), and Re(I) complexes, studied in acetonitrile, the transitions associated with the lowest-energy absorption band are of (MLCT)-M-1 (metal-to-ligand charge transfer) nature. The emission properties, as observed at room temperature and at 77 K, can be described as follows: (i) the Fe(II) complexes do not emit, either at room temperature or at 77 K; (ii) the room-temperature emission of the Ru(II) complexes (phi(em) textbackslashtextbackslashtextgreater 10(-3), tau in the mu s range) is of mixed (MLCT)-M-3/(LC)-L-3 character (and similarly at 77 K); and (iii) the room-temperature emission of the Re(I) complexes (phi(em) similar to 3 x 10(-3), tau textbackslashtextbackslashtextless 1 ns) is of (MLCT)-M-3 character and becomes of (LC)-L-3 (ligand-centered) character (tau in the ms time scale) at 77 K. The interplay of the involved excited states in determining the luminescence output is examined.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The redox behaviour, optical-absorption spectra and emission properties of U-shaped and elongated disubstituted biisoquinoline ligands and of derived octahedral Fe(II), Ru(II), and Re(I) complexes are reported. The ligands are 8,8'-dichloro-3,3'-biisoquinoline (1), 8,8'-dianisyl-3,3'-biisoquinoline (2), and 8,8'-di(phenylanisyl)-3,3'-biisoquinoline (3), and the complexes are [Fe(2)(3)](2+), [Fe(3)(3)](2+), [Ru(1)(phen)(2)](2+), [Ru(2)(3)](2+), [Ru(3)(3)](2+), [Re(2)(py)(CO)(3)](+), and [Re(3)(py)(CO)(3)](+). For the ligands, the optical properties as observed in dichloromethane are in line with expectations based on the predominant (1)pi pi* nature of the involved excited states, with contributions at lower energies from (1)n pi* and (ILCT)-I-1 (intraligand charge transfer) transitions. For all of the Fe(II), Ru(II), and Re(I) complexes, studied in acetonitrile, the transitions associated with the lowest-energy absorption band are of (MLCT)-M-1 (metal-to-ligand charge transfer) nature. The emission properties, as observed at room temperature and at 77 K, can be described as follows: (i) the Fe(II) complexes do not emit, either at room temperature or at 77 K; (ii) the room-temperature emission of the Ru(II) complexes (phi(em) textbackslashtextbackslashtextgreater 10(-3), tau in the mu s range) is of mixed (MLCT)-M-3/(LC)-L-3 character (and similarly at 77 K); and (iii) the room-temperature emission of the Re(I) complexes (phi(em) similar to 3 x 10(-3), tau textbackslashtextbackslashtextless 1 ns) is of (MLCT)-M-3 character and becomes of (LC)-L-3 (ligand-centered) character (tau in the ms time scale) at 77 K. The interplay of the involved excited states in determining the luminescence output is examined. |
Sauvage, Jean-Pierre ; Collin, Jean-Paul ; Faiz, Jonathan A; Frey, Julien ; Heitz, Valerie ; Tock, Christian Porphyrin-based catenanes and rotaxanes Journal Article In: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 12 (8), pp. 881–905, 2008, ISSN: 1088-4246. @article{sauvage_porphyrin-based_2008, title = {Porphyrin-based catenanes and rotaxanes}, author = {Sauvage, Jean-Pierre and Collin, Jean-Paul and Faiz, Jonathan A. and Frey, Julien and Heitz, Valerie and Tock, Christian}, doi = {10.1142/S1088424608000285}, issn = {1088-4246}, year = {2008}, date = {2008-01-01}, journal = {JOURNAL OF PORPHYRINS AND PHTHALOCYANINES}, volume = {12}, number = {8}, pages = {881--905}, abstract = {Catenanes and rotaxanes containing porphyrin subunits have become popular synthetic targets because of the large variety of available synthetic strategies including the coordination chemistry of metalated porphyrins, coupled with the many attractive physical properties of porphyrins. The present review article outlines various synthetic approaches and templating strategies that have been used to prepare a range of mechanically interlocked architectures that incorporate porphyrins as fundamental subunits either grafted onto macrocycles or as stoppers. These species are of interest in relation to recreating natural processes such as the photosynthetic apparatus or enzyme binding sites. In recent years, “Molecular machines” have also experienced a spectacular development. Porphyrin-based rotaxanes are particularly promising in relation to this research field, this is shown by the elaboration of a “molecular press” whose properties will be briefly discussed in this review. Copyright (c) 2008 Society of Porphyrins & Phthalocyanines.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Catenanes and rotaxanes containing porphyrin subunits have become popular synthetic targets because of the large variety of available synthetic strategies including the coordination chemistry of metalated porphyrins, coupled with the many attractive physical properties of porphyrins. The present review article outlines various synthetic approaches and templating strategies that have been used to prepare a range of mechanically interlocked architectures that incorporate porphyrins as fundamental subunits either grafted onto macrocycles or as stoppers. These species are of interest in relation to recreating natural processes such as the photosynthetic apparatus or enzyme binding sites. In recent years, “Molecular machines” have also experienced a spectacular development. Porphyrin-based rotaxanes are particularly promising in relation to this research field, this is shown by the elaboration of a “molecular press” whose properties will be briefly discussed in this review. Copyright (c) 2008 Society of Porphyrins & Phthalocyanines. |
Champin, Benoit ; Sartor, Valerie ; Sauvage, Jean-Pierre A highly rigid ditopic conjugate with orthogonal coordination axes and its zinc(II) and copper(II) complexes Journal Article In: NEW JOURNAL OF CHEMISTRY, 32 (6), pp. 1048–1054, 2008, ISSN: 1144-0546. @article{champin_highly_2008, title = {A highly rigid ditopic conjugate with orthogonal coordination axes and its zinc(II) and copper(II) complexes}, author = {Champin, Benoit and Sartor, Valerie and Sauvage, Jean-Pierre}, doi = {10.1039/b713367g}, issn = {1144-0546}, year = {2008}, date = {2008-01-01}, journal = {NEW JOURNAL OF CHEMISTRY}, volume = {32}, number = {6}, pages = {1048--1054}, abstract = {A highly rigid ditopic ligand has been prepared which consists of a terpy fragment connected in the back to a phen nucleus via a 1,4-phenylene linker. The chemical structure of the presently reported ligand is such that the coordination axes of the two chelates are orthogonal to one another. The reaction of this phen-terpy conjugate with zinc(II) surprisingly affords in good yield a dinuclear complex in spite of the tension of the generated structure, whereas coordination of copper(II) centres to the two-chelate ligand enables the formation of the trinuclear complex also.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A highly rigid ditopic ligand has been prepared which consists of a terpy fragment connected in the back to a phen nucleus via a 1,4-phenylene linker. The chemical structure of the presently reported ligand is such that the coordination axes of the two chelates are orthogonal to one another. The reaction of this phen-terpy conjugate with zinc(II) surprisingly affords in good yield a dinuclear complex in spite of the tension of the generated structure, whereas coordination of copper(II) centres to the two-chelate ligand enables the formation of the trinuclear complex also. |
1975 |
Hartman, F C; LaMuraglia, G M; Tomozawa, Y; Wolfenden, R The influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group Journal Article In: Biochemistry, 14 (24), pp. 5274–5279, 1975, ISSN: 0006-2960. @article{hartman_influence_1975, title = {The influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group}, author = {Hartman, F. C. and LaMuraglia, G. M. and Tomozawa, Y. and Wolfenden, R.}, issn = {0006-2960}, year = {1975}, date = {1975-12-01}, journal = {Biochemistry}, volume = {14}, number = {24}, pages = {5274--5279}, abstract = {Ionization effects on the binding of the potential transition state analogues 2-phosphoglycolate and 2-phosphoglycolohydroxamate appear to be attributable to the changing state of ionization of the ligands themselves, therefore it is unnecessary to postulate the additional involvement of an ionizing residue at the active site of triosephosphate isomerase to explain the influence of changing pH on Ki in the neutral range. The binding of the competitive inhibitor inorganic sulfate is insensitive to changing pH in the neutral range. 3-Chloroacetol sulfate, synthesized as an active-site-specific reagent for triosephosphate isomerase, is used to provide an indication of the pKa of the essential carboxyl group of this enzyme. Previously described active-site-specific reagents for the isomerase were phosphate esters, and their changing state of ionization (accompanied by possible changes in their affinity for the active site) may have complicated earlier attempts to determine the pKa of the essential carboxyl group from the pH dependence of the rate of inactivation. Being a strong monoprotic acid, chloroacetol sulfate is better suited to the determination of the pKa of the carboxyl group. Chloroacetol sulfate inactivates triosephosphate isomerase by the selective esterification of the same carboxyl group as that which is esterified by the phosphate esters described earlier. From the pH dependence of the rate of inactivation of yeast triosephosphate isomerase, the apparent pKa of the active-site carboxyl group is estimated as 3.9 +/- 0.1.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Ionization effects on the binding of the potential transition state analogues 2-phosphoglycolate and 2-phosphoglycolohydroxamate appear to be attributable to the changing state of ionization of the ligands themselves, therefore it is unnecessary to postulate the additional involvement of an ionizing residue at the active site of triosephosphate isomerase to explain the influence of changing pH on Ki in the neutral range. The binding of the competitive inhibitor inorganic sulfate is insensitive to changing pH in the neutral range. 3-Chloroacetol sulfate, synthesized as an active-site-specific reagent for triosephosphate isomerase, is used to provide an indication of the pKa of the essential carboxyl group of this enzyme. Previously described active-site-specific reagents for the isomerase were phosphate esters, and their changing state of ionization (accompanied by possible changes in their affinity for the active site) may have complicated earlier attempts to determine the pKa of the essential carboxyl group from the pH dependence of the rate of inactivation. Being a strong monoprotic acid, chloroacetol sulfate is better suited to the determination of the pKa of the carboxyl group. Chloroacetol sulfate inactivates triosephosphate isomerase by the selective esterification of the same carboxyl group as that which is esterified by the phosphate esters described earlier. From the pH dependence of the rate of inactivation of yeast triosephosphate isomerase, the apparent pKa of the active-site carboxyl group is estimated as 3.9 +/- 0.1. |
Caras, I; Shapiro, B Partial purification and properties of microsomal phosphatidate phosphohydrolase from rat liver Journal Article In: Biochimica Et Biophysica Acta, 409 (2), pp. 201–211, 1975, ISSN: 0006-3002. @article{caras_partial_1975, title = {Partial purification and properties of microsomal phosphatidate phosphohydrolase from rat liver}, author = {Caras, I. and Shapiro, B.}, issn = {0006-3002}, year = {1975}, date = {1975-11-01}, journal = {Biochimica Et Biophysica Acta}, volume = {409}, number = {2}, pages = {201--211}, abstract = {Microsomal phosphatidate phosphohydrolase (phosphatidate phosphatase EC 3.1.3.4) was solubilized and fractionated to yield at least two distinct enzymatically active fractions. One, denoted FA, was non-specific, had a relatively high Km for phosphatidic acid and was insensitive to inhibition by diacylglycerol. The second fraction, FB, was specific for phosphatidates, had a low Km, and was inhibited, non-competitively, by diacylglycerol. FA exhibited a sigmoid substrate-activity curve. The isolated FB aggregated to particles of about 10(6) in the absence of salts and could be dissociated by the addition of monovalent cations at ionic strength 0.4-0.6 to about 2-10(5) daltons and thereby doubled its activity. Dissociation was time- and temperature-dependent. F- was inhibitory. Divalent ions were not required for the activity of FA or FB and inhibited at concentrations exceeding 1 mM.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Microsomal phosphatidate phosphohydrolase (phosphatidate phosphatase EC 3.1.3.4) was solubilized and fractionated to yield at least two distinct enzymatically active fractions. One, denoted FA, was non-specific, had a relatively high Km for phosphatidic acid and was insensitive to inhibition by diacylglycerol. The second fraction, FB, was specific for phosphatidates, had a low Km, and was inhibited, non-competitively, by diacylglycerol. FA exhibited a sigmoid substrate-activity curve. The isolated FB aggregated to particles of about 10(6) in the absence of salts and could be dissociated by the addition of monovalent cations at ionic strength 0.4-0.6 to about 2-10(5) daltons and thereby doubled its activity. Dissociation was time- and temperature-dependent. F- was inhibitory. Divalent ions were not required for the activity of FA or FB and inhibited at concentrations exceeding 1 mM. |
Giangrande, M; Kim, Y W; Mizukami, H N-terminal spin label studies of hemoglobin, Ligand and pH dependence Journal Article In: Biochimica Et Biophysica Acta, 412 (1), pp. 187–193, 1975, ISSN: 0006-3002. @article{giangrande_n-terminal_1975, title = {N-terminal spin label studies of hemoglobin, Ligand and pH dependence}, author = {Giangrande, M. and Kim, Y. W. and Mizukami, H.}, issn = {0006-3002}, year = {1975}, date = {1975-11-01}, journal = {Biochimica Et Biophysica Acta}, volume = {412}, number = {1}, pages = {187--193}, abstract = {Human hemoglobin was spin labeled with 4-isothiocanato-2,2,6,6-tetramethyl-piperdinooxyl, which is known to bind specifically to the N-terminal alpha-amino groups of proteins and slightly to the reactive sulfhydryl groups. Electron spin resonance (ESR) analysis indicated a partially resolved five-line spectrum, suggesting that the label was attached to at least two different binding sites. Using specific blocking reagents prior to spin labeling, the two binding sites were attributed to the sulfhydryl group of beta-93 (immobile) and the alpha-amino group of the N-terminal valines (mobile). The relative motion of the spin at one set of binding sites was restricted regardless of the state of ligation and pH, while the motion at the other site showed dependence on those parameters, e.g. the spin-labeled N-terminal ends of deoxyhemoglobin have restricted motion at all pH ranges studied, while those of oxyhemoglobin are relatively free to move at the basic pH range, but become more restricted in the acidic pH range.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Human hemoglobin was spin labeled with 4-isothiocanato-2,2,6,6-tetramethyl-piperdinooxyl, which is known to bind specifically to the N-terminal alpha-amino groups of proteins and slightly to the reactive sulfhydryl groups. Electron spin resonance (ESR) analysis indicated a partially resolved five-line spectrum, suggesting that the label was attached to at least two different binding sites. Using specific blocking reagents prior to spin labeling, the two binding sites were attributed to the sulfhydryl group of beta-93 (immobile) and the alpha-amino group of the N-terminal valines (mobile). The relative motion of the spin at one set of binding sites was restricted regardless of the state of ligation and pH, while the motion at the other site showed dependence on those parameters, e.g. the spin-labeled N-terminal ends of deoxyhemoglobin have restricted motion at all pH ranges studied, while those of oxyhemoglobin are relatively free to move at the basic pH range, but become more restricted in the acidic pH range. |
0000 |
0000. @book{noauthor_laboratoire_nodate, title = {Laboratoire des Systèmes Complexes hors équilibre (Thomas HERMANS) textbackslashtextbackslashtextbar Institut de Science et d'Ingénierie Supramoléculaires}, url = {http://isis.unistra.fr/laboratoire-des-systemes-complexes-hors-equilibre-thomas-hermans/}, urldate = {2018-10-08}, keywords = {}, pubstate = {published}, tppubtype = {book} } |
, Molecule–Graphene Hybrid Materials with Tunable Mechanoresponse: Highly Sensitive Pressure Sensors for Health Monitoring Journal Article In: 0000. @article{, title = {Molecule–Graphene Hybrid Materials with Tunable Mechanoresponse: Highly Sensitive Pressure Sensors for Health Monitoring}, author = { }, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Journal Article In: 0000. @article{, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Publications
2008 |
The elastic properties of the structurally characterized myosin II s2 subdomain: A molecular dynamics and normal mode analysis Journal Article In: BIOPHYSICAL JOURNAL, 94 (10), pp. 3779–3789, 2008, ISSN: 0006-3495. |
A differential fluctuation theorem Journal Article In: JOURNAL OF PHYSICAL CHEMISTRY B, 112 (19), pp. 6168–6174, 2008, ISSN: 1520-6106. |
Glycodynamers: Dynamic analogs of arabinofuranoside oligosaccharides Journal Article In: BIOPOLYMERS, 89 (5), pp. 486–496, 2008, ISSN: 0006-3525. |
Naphthyridine-based helical foldamers and macrocycles: Synthesis, cation binding, and supramolecular assemblies Journal Article In: JOURNAL OF ORGANIC CHEMISTRY, 73 (7), pp. 2481–2495, 2008, ISSN: 0022-3263. |
A [3]rotaxane with two porphyrinic plates acting as an adaptable receptor Journal Article In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (14), pp. 4592+, 2008, ISSN: 0002-7863. |
PRES 17-Synthesis of a tetra-substituted porphyrin for use in a [6]rotaxane reminiscent of a press Journal Article In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 235 , 2008, ISSN: 0065-7727. |
Modulation of surface plasmon coupling-in by one-dimensional surface corrugation Journal Article In: NEW JOURNAL OF PHYSICS, 10 , 2008, ISSN: 1367-2630. |
Emission and excitation contributions to enhanced single molecule fluorescence by gold nanometric apertures Journal Article In: OPTICS EXPRESS, 16 (5), pp. 3008–3020, 2008, ISSN: 1094-4087. |
Coupling efficiency of light to surface plasmon polariton for single subwavelength holes in a gold film Journal Article In: OPTICS EXPRESS, 16 (5), pp. 3420–3429, 2008, ISSN: 1094-4087. |
Plasmonic photon sorters for spectral and polarimetric imaging Journal Article In: NATURE PHOTONICS, 2 (3), pp. 161–164, 2008, ISSN: 1749-4885. |
Probing local surface potential of quasi-one-dimensional systems: A KPFM study of P3HT nanofibers Journal Article In: ADVANCED FUNCTIONAL MATERIALS, 18 (6), pp. 907–914, 2008, ISSN: 1616-301X. |
Helical diastereomerism in self-organization of molecular strands Journal Article In: REVISTA DE CHIMIE, 59 (3), pp. 255–259, 2008, ISSN: 0034-7752. |
Nanoaperture-enhanced fluorescence: Towards higher detection rates with plasmonic metals Journal Article In: PHYSICAL REVIEW B, 77 (4), 2008, ISSN: 1098-0121. |
Nanophotonic components utilizing channel plasmon polaritons Inproceedings In: {Kawata, S; Shalaev, VM ; Tsai, DP} (Ed.): PLASMONICS: NANOIMAGING, NANOFABRICATION, AND THEIR APPLICATIONS IV, SPIE, 2008, ISBN: 978-0-8194-7253-3. |
How subunit coupling produces the gamma-subunit rotary motion in F-1-ATPase Journal Article In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 (4), pp. 1192–1197, 2008, ISSN: 0027-8424. |
Hydrodynamic description of protein folding Journal Article In: PHYSICAL REVIEW LETTERS, 100 (1), 2008, ISSN: 0031-9007. |
Force generation in kinesin hinges on cover-neck bundle formation Journal Article In: STRUCTURE, 16 (1), pp. 62–71, 2008, ISSN: 0969-2126. |
Photovoltaic charge generation visualized at the nanoscale: A proof of principle Journal Article In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (3), pp. 780+, 2008, ISSN: 0002-7863. |
Subnanometer-resolved patterning of bicomponent self-assembled monolayers on Au(111) Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (13), pp. 2484–2488, 2008, ISSN: 1433-7851. |
Light-powered electrical switch based on cargo-lifting azobenzene monolayers Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (18), pp. 3407–3409, 2008, ISSN: 1433-7851. |
Pre-programmed bicomponent porous networks at the solid-liquid interface: the low concentration regime Journal Article In: CHEMICAL COMMUNICATIONS, (42), pp. 5289–5291, 2008, ISSN: 1359-7345. |
Self-assembly of hydrogen-bond assisted supramolecular azatriphenylene architectures Journal Article In: SOFT MATTER, 4 (2), pp. 303–310, 2008, ISSN: 1744-683X. |
Self-assembly of discotic molecules into mesoscopic crystals by solvent-vapour annealing Journal Article In: SOFT MATTER, 4 (10), pp. 2064–2070, 2008, ISSN: 1744-683X. |
Exploring electronic transport in molecular junctions by conducting atomic force microscopy Incollection In: {Samori, P} (Ed.): STM AND AFM STUDIES ON (BIO)MOLECULAR SYSTEMS: UNRAVELLING THE NANOWORLD, 285 , pp. 157–202, 2008, ISBN: 978-3-540-78394-7. |
DOSY NMR experiments as a tool for the analysis of constitutional and motional dynamic processes: Implementation for the driven evolution of dynamic combinatorial libraries of helical strands Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (12), pp. 2235–2239, 2008, ISSN: 1433-7851. |
Glycodynamers: Fluorescent dynamic analogues of polysaccharides Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (19), pp. 3556–3559, 2008, ISSN: 1433-7851. |
A Jubilee 60th Congress of the Association of Czech and Slovak chemical company. Olomouc, 1st-4th September 2008 - Abstracts Journal Article In: CHEMICKE LISTY, 102 (8), pp. 595–759, 2008, ISSN: 0009-2770. |
Structural selection in G-quartet-based hydrogels and controlled release of bioactive molecules Journal Article In: CHEMISTRY-AN ASIAN JOURNAL, 3 (1), pp. 134–139, 2008, ISSN: 1861-4728. |
Metallodynamers: Neutral double-dynamic metallosupramolecular polymers Journal Article In: CHEMISTRY-AN ASIAN JOURNAL, 3 (8-9), pp. 1324–1335, 2008, ISSN: 1861-4728. |
Synthesis of components for the generation of constitutional dynamic analogues of nucleic acids Journal Article In: HELVETICA CHIMICA ACTA, 91 (1), pp. 1–20, 2008, ISSN: 0018-019X. |
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor Journal Article In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47 (23), pp. 4432–4435, 2008, ISSN: 1433-7851. |
Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents Journal Article In: CHEMICAL COMMUNICATIONS, (38), pp. 4619–4621, 2008, ISSN: 1359-7345. |
Nucleic acid encoding to program self-assembly in chemical biology Journal Article In: CHEMICAL SOCIETY REVIEWS, 37 (7), pp. 1330–1336, 2008, ISSN: 0306-0012. |
Iron(II)-templated synthesis of [3]rotaxanes by passing two threads through the same ring Journal Article In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (2), pp. 448+, 2008, ISSN: 0002-7863. |
Quantitative formation of a tetraporphyrin [2] catenane via copper and zinc coordination Journal Article In: CHEMICAL COMMUNICATIONS, (42), pp. 5396–5398, 2008, ISSN: 1359-7345. |
Fe(II), Ru(II) and Re(I) complexes of endotopic, sterically non-hindering, U-shaped 8,8'-disubstituted-3,3'-biisoquinoline ligands: syntheses and spectroscopic properties Journal Article In: DALTON TRANSACTIONS, (4), pp. 491–498, 2008, ISSN: 1477-9226. |
Porphyrin-based catenanes and rotaxanes Journal Article In: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 12 (8), pp. 881–905, 2008, ISSN: 1088-4246. |
A highly rigid ditopic conjugate with orthogonal coordination axes and its zinc(II) and copper(II) complexes Journal Article In: NEW JOURNAL OF CHEMISTRY, 32 (6), pp. 1048–1054, 2008, ISSN: 1144-0546. |
1975 |
The influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group Journal Article In: Biochemistry, 14 (24), pp. 5274–5279, 1975, ISSN: 0006-2960. |
Partial purification and properties of microsomal phosphatidate phosphohydrolase from rat liver Journal Article In: Biochimica Et Biophysica Acta, 409 (2), pp. 201–211, 1975, ISSN: 0006-3002. |
N-terminal spin label studies of hemoglobin, Ligand and pH dependence Journal Article In: Biochimica Et Biophysica Acta, 412 (1), pp. 187–193, 1975, ISSN: 0006-3002. |
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Molecule–Graphene Hybrid Materials with Tunable Mechanoresponse: Highly Sensitive Pressure Sensors for Health Monitoring Journal Article In: 0000. |
Journal Article In: 0000. |