Fabrice Gallou

Chemical & Analytical Development, Novartis Pharma

Basel,-Switzerland

Abstract:

During our evaluation of the potential of surfactant technology in collaboration with Professors Lipshutz and Handa,^{(1,2, 3)} we have identified a variety of straightforward and highly advantageous transformations and applied them successfully on-scale on various chemo and biocatalytic transformations.⁽⁴⁾ Implementation of the technology typically results into significant benefits across our entire portfolio, not just from an environmental standpoint but also from an economic and productivity perspective. To name a few: reduction of organic solvent consumption, water use and cycle time, milder reaction conditions, improved yields and selectivities, which all contribute to improved process performance and lower manufacturing costs.⁽⁵⁾

These surfactant mediated reactions can be up-scaled in the already existing multi-purpose facilities of pharmaceutical or chemical organizations, using a catalytic amount of a combination of a non-ionic designer surfactant (e.g. TPGS-750-M, FI-750-M) in water, and a well-chosen organic co-solvent instead of traditional and undesirable organic solvents.⁽⁶⁾ We now start gaining insight onto the physical phenomena involved and the role of the various components of the system and utilize this know-how to design even better catalytic systems.⁽⁷⁾

[1] See for example: Science 2015, 349, 1087; Ang. Chem. Int. Ed. 2016, 55, 8979; Ang. Chem. Int. Ed. 2016, 55, 4914.

[2] J. Am. Chem. Soc. 2013, 135, 17707; Org. Lett. 2015, 17, 4734; Org. Lett. 2015, 17, 3968; Org. Proc. Res. Dev. 2016, 20, 1104.

[3] Chem. Sci. 2017, 8, 6354; ACS Catal. 2018, 7, 10, 7245.

[4] Green Chem. 2016, 18, 14.  Nat. Rev. Chem. 2018, 2, 306. Nature Comm. 2019, 10, 2169.

[5] ACS Sustain Chem. Eng. 2016, 4, 5838.

[6] Org. Proc. Res. Dev. 2016, 20, 1388.

[7] Org. Lett. 2017, 19, 194; Eur. J. Org. Chem. 2018, 24, 6778.