June 2022
1st ISIS Minisymposium on Catalysis
Shedule: 13.30-14.30 - Prof. Bill Morandi (ETH Zurich) "Recent developments in shuttle catalysis" 14.30-15.30 - Prof. Bas de Bruin (University of Amsterdam) “Bio-inspired synthesis of ring compounds using metalloradical catalysis” - break- 16.00-17.00 - Prof. Philippe Dauban (Paris Saclay) “Dirhodium(II) catalysis and its application to selective nitrene additions”
Find out more »September 2022
Prof. Cynthia Burrows ” Peering and Poking at RNA in Bacteria, Viruses and Vaccines”
Cynthia Burrows, Thatcher Presidential Chair and Distinguished Professor Department of Chemistry, University of Utah, Salt Lake City Nanopore-forming transmembrane proteins such as α-hemolysin provide the opportunity for electrophoretic capture and analysis of individual DNA or RNA strands in the protein cavity. Using an in-house device, we observed single-molecule dynamics of DNA mismatches, cytosine epigenetic modifications, and the unfolding of G-quadruplexes and i-motifs. Next, with the current availability of Oxford Nanopore Technology, we have been able to apply direct RNA sequencing…
Find out more »October 2022
Prof. Huw Davies “Collaborative Approach for Catalyst-Controlled Site-Selective and Enantioselective C-H Functionalization”
Huw M. L. Davies Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322 E-Mail : hmdavie@emory.edu One of the signature challenges of the NSF Center for Chemical Innovation on Selective C-H Functionalization (CCHF) has been the design of catalysts to control site selective C-H functionalization reactions. Dirhodium tetracarboxylates have been very effective in this regard because the carboxylate ligands self-assemble on coordination to the dirhodium to generate high symmetry chiral catalysts of defined shape and size. This presentation…
Find out more »Prof. Dennis Gillingham “Chemical modifications of DNA and how they inspired a new method for target protein degradation”
Prof. Dennis Gillingham University of Basel “Chemical modifications of DNA and how they inspired a new method for target protein degradation” Brief Abstract: Guanine is one of the most reactive bases in DNA and is often the site of action of DNA-modifying drugs. Alkylation damage at oxygen in position six of guanine is directly repaired by an unusual suicide protein known as methylguanine methyltransferase (MGMT). The protein performs an SN2 reaction at the alkylation damage, thus directly accepting the alkyl…
Find out more »November 2022
Prof. Nathalie Katsonis “Chemical origin of protocells and motility in primeval oceans”
Prof. Nathalie Katsonis University of Groningen Our research aims at uncovering some of the molecular mechanisms at the origin of functional movement, in systems of interacting molecules. Movement is a defining feature of life. It enables bacteria to overcome diffusion when seeking nutrients and is essential in eukaryotes to achieve embryogenesis. This functional movement is born at the level of molecular interactions, yet we still do not know how motile molecular systems emerged in the early Earth’s oceans. It is…
Find out more »December 2022
Alexandre Detappe “Nanomedicine development – The case of Multiple Myeloma”
Alexandre Detappe ICANS - Institut de cancérologie Strasbourg Europe Abstract In the past decades, considerable progress has been made in our understanding and treatment of multiple myeloma. Several challenges remain including our abilities to longitudinally image tumor responses to treatment, to combine various therapeutic agents with different mechanisms of action but with overlapping toxicities, and to efficiently harness the power of the immune system to augment remission and/or to induce permanent cures. Nanomedicine may help to address many of…
Find out more »January 2023
Dr. Pascal Mayer “Pluri-disciplinarity at work: From Next Generation DNA Sequencing to Next Generation Therapeutics”
Dr. Pascal Mayer Alphanosos
Find out more »Prof. Sara Bals “3D Characterization of Nanomaterials under Relevant Conditions by Electron Tomography”
Prof. Sara Bals Electron Microscopy for Materials Science (EMAT) and NANOlab Center of Exellence, University of Antwerp, Antwerp 2020, Belgium Abstract Electron tomography enables one to measure the morphology and composition of nanostructures in three dimensions (3D), even at atomic resolution. However, an emerging challenge is to fully understand the connection between the 3D structure and properties under realistic conditions, including high temperatures as well as in the presence of liquids and gases. Our recent experiments demonstrate the progress…
Find out more »February 2023
Prof. Hagan Bayley “The Remarkable Science of Nanopores: from Gene Sequencing to Organ Repair”
Prof. Hagan Bayley University of Oxford Hagan Bayley is the Professor of Chemical Biology at the University of Oxford. His research lies at the interface between chemistry and biology. Using protein chemistry, organic chemistry, and biophysics, his lab explores the folding, assembly, and function of transmembrane channels and pores. Stemming from these findings, his lab also develops engineered protein nanopores for applications in biotechnology including stochastic sensing, ultrarapid biopolymer sequencing and single-molecule covalent chemistry. More recently, the Bayley lab…
Find out more »Prof. Maria Jesus Vicent “Designing Personalized Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients”
Prof. Maria Jesus Vicent Polymer Therapeutics Lab, Prince Felipe Research Center (CIPF) Valencia, Spain Abstract Breast cancer, the most prevalent tumor in women worldwide1, still lacks effective treatment approaches that increase survival rates and reduce side effects. The implementation of polypeptide-based polymer-drug conjugation strategies represents a promising approach2. The physico-chemical parameters of a polypeptide-conjugate, and hence its biological performance, are defined by an intricate interplay of multiple structural factors. This highlights the need for detailed structure-activity relationship studies to develop…
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