Institut de Science et d'Ingénierie Supramoléculaires

Guy Bertrand UCSD-CNRS Joint Research Chemistry Laboratory (UMI 3555), Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0343 (USA) (guybertrand@ucsd.edu) Over the years, the success of homogeneous catalysis can be attributed largely to the development of a diverse range of ligand frameworks that have been used to tune the behavior of the various systems. Spectacular results in this area have been achieved using cyclic diaminocarbenes, the so-called N-heterocyclic carbenes (NHCs), mainly because of their strong…

Perspectives in molecular tectonics: from crystalline molecular networks to networks of crystals Mir Wais Hosseini Laboratoire de Tectonique Moléculaire, UMR UDS-CNRS 7140, University of Strasbourg, Institut Le Bel, 4, rue Blaise Pascal, 67000 Strasbourg, France, e-mail hosseini@unistra.fr Bridging the gap between microscopic (atoms and molecules) and macroscopic (materials) worlds is challenging and requires construction strategies. At the intersection of supramolecular and solid state chemistry and material sciences, we have developed an approach called molecular tectonics. This approach is based on…

Enantioselective Photo-Organocatalysis: Making Chiral Molecules with Light Paolo Melchiorre1,2 1ICIQ - Institute of Chemical Research of Catalonia, Av. Països Catalans 16, 43007 (Tarragona, Spain); 2ICREA - Pg. Lluís Companys 23, 08010 (Barcelona, Spain) e-mail: pmelchiorre@iciq.es Light-driven processes considerably enrich the modern synthetic repertoire, offering a potent way to build complex organic frameworks.1 In contrast, it is difficult to develop enantioselective catalytic photoreactions that can create chiral molecules with a well-defined three-dimensional arrangement.2 Recently, our research laboratories3 has started a program…

A holy grail of nano-technology is to create truly complex, multi-component structures by self-assembly. Most self-assembly has focused on the creation of "structural complexity". In my talk, I will discuss "Addressable Complexity": the creation of structures that contain hundreds or thousands of distinct building blocks that all have to find their place in a 3D structure. Recent experiments have demonstrated the feasibility of making such structures. Simulation and theory yield surprising insights that can inform the design of novel structures…

CONFERENCE Professor Ivan APRAHAMIAN Department of Chemistry, Dartmouth College Hanover, NH. Hydrazone-Based Switches and Fluorophores Jeudi 27 avril 2017 16:30 ISIS, salle de conférence - 8 allée Gaspard Monge, Campus Esplanade

  Lutz H. Gade Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg email: lutz.gade@uni-heidelberg.de Meridionally coordinating chiral tridentate ligands, frequently referred to as “pincers”, provide the structural platform for the construction of efficient stereodirecting molecular environments. Whilst many of the known chiral systems of the “pincer” type perform relatively poorly in enantioselective catalysis due to certain lack of control of substrate orientation, their assembly from rigid heterocyclic units recently has given rise to several highly enantioselective catalysts which…

NMR STUDIES OF Protein DYNAMICS – from fundamental biophysics TO BIOLOGICAL function Martin Blackledge Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale, Grenoble   martin.blackledge@ibs.fr The precision with which X-ray crystallography and electron microscopy provides structural models of biologically active protein conformations belies an easily overlooked dilemma. Proteins are inherently dynamic, exhibiting conformational freedom on many timescales,1 implicating structural rearrangements that play a major role in molecular interaction, thermodynamic stability and molecular recognition and signalling. Static structural biology…