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May 2017

Dr. Martin Blackledge “NMR studies of protein dynamics – from fundamental biophysics to biological function”

May 29, 2017 @ 4:30 pm
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NMR STUDIES OF Protein DYNAMICS – from fundamental biophysics TO BIOLOGICAL function Martin Blackledge Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale, Grenoble   martin.blackledge@ibs.fr The precision with which X-ray crystallography and electron microscopy provides structural models of biologically active protein conformations belies an easily overlooked dilemma. Proteins are inherently dynamic, exhibiting conformational freedom on many timescales,1 implicating structural rearrangements that play a major role in molecular interaction, thermodynamic stability and molecular recognition and signalling. Static structural biology…

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June 2017

Prof.Dr.María Vallet Regí “Design of drug nanocarriers”

June 12, 2017 @ 4:30 pm
ISIS,

Prof.Dr.María Vallet Regí Grupo de Investigación Biomateriales Inteligentes GIBI-CIBER-BBN Dpto. Química Inorgánica y Bioinorgánica Fac. Farmacia – UCM Madrid – España http://www.ucm.es/valletregigroup https://vimeo.com/190054397   titre : Design of drug nanocarriers' description : This lecture will describe the production of smart nanosystems capable of: carrying antitumor agents selectively to a tumor tissue, and  releasing them there thanks to the application of an external stimulus. We use the term smart because those nanocarriers are able to release the drugs when and where…

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September 2017

Dominique Massiot “Order and disorder at the nanoscale geometry, chemistry, topology”

September 18, 2017 @ 4:30 pm

Dominique    Massiot CEMHTI,    UPR3079    Orléans http://www.cemhti.cnrs-orleans.fr/ Controlling    the    chemistry    and    the    structure    of    materials    is    a    key    to    understanding,    tuning,    and    enhancing    their    properties.    However,    detailed    structural    and    chemical    characterization    of    materials    in    three    dimensions,    whether    homogeneous    or    heterogeneous,    remains    challenging    at    the    atomic    and    nanometer    length    scales.    We    have    developed    a    panel    of    methods    and    approaches    that    combine    new    experimental    solid-state    NMR    methods    and    DFT-based    in    silico    modelling,    which    jointly    enable    characterization    of    chemical    and    geometrical    order,    as    well  …

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Francesco Stellacci “Supramolecular approaches to Engineer Materials Interactions with Viruses: From Stabilization to Virucidal Drugs”

September 25, 2017 @ 11:00 am
ISIS,

Francesco Stellacci Institute of Materials, and Interfaculty Bioengineering Institute, Ecole Polytecnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland Email: francesco.stellacci@epfl.ch Viruses kill every day in large numbers especially in low-income countries. Any given day ~1600 children age 1 to 5 die of diarrhea (mostly due to rotavirus). More than 5000 people have died of Ebola in the last outbreak. On the other hand, viruses also save lives as vaccines; unfortunately, because of their thermal instability, vaccines need constant refrigeration. This…

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October 2017

Minisymposium entitled “Non-equilibrium Supramolecular Self-assembly”

October 5, 2017 @ 2:30 pm - 5:15 pm
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Minisymposium "Non-equilibrium supramolecular self-assembly" 14:30-15:15 Prof. Job Boekhoven (Technical University of Munich) Supramolecular materials with a tunable lifetime 15:15-16:00 Prof. Beatriu Escuder (Universitat Jaume I) Complex functional supramolecular gels 16:00-16:30 Coffee break 16:30-17:15 Prof. Anja Palmans (Eindhoven University of Technology) Controlling function through structure in dynamic systems Related: 6 Oct. 2017 9:30 (same location) – PhD defense Jorge LEIRA-IGLESIAS “Dissipative supramolecular polymerization mediated by chemical fuels”

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Prof. Dr. Thorsten Stafforst “Site-specific Manipulation of Nucleic Acids with (Bio)Chemical Tools”

October 9, 2017 @ 4:30 pm
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Prof. Dr. Thorsten Stafforst Interfaculty Institute of Biochemistry, Auf der Morgenstelle 15, 72076 Tübingen (Germany) thorsten.stafforst@uni-tuebingen.de www.ifib.uni-tuebingen.de/research/stafforst/   RNA modifications shape the expression of genetic information in many ways. Tools to manipulate single nucleobases at specific sites in selected transcripts in vivo are rare. We are engineering artifical RNA-guided proteins that allow to perform site-directed RNA editing in a highly rational and specific way (1-5). We will present new data that demonstrate highly specific and parallel editing of several endogenous…

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November 2017

Pr Thorsten Bach “Chirality and Light: Enantioselective Catalysis of Photochemical Reactions”

November 20, 2017 @ 4:30 pm
ISIS,

Pr Thorsten Bach Technische Universität München Chirality and Light: Enantioselective Catalysis of Photochemical Reactions   Photocycloaddition reactions belong undisputedly to the most important reaction classes in photochemistry. The creation of up to four new stereogenic centers in a single step and the further use of the formed cyclobutane rings – either directly or after appropriate ring opening – are hallmarks of this powerful transformation. In our group, we have studied two different approaches to achieve a catalytic enantioselective reaction…

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Les Rencontres d’ISIS ” Venez découvrir la nature chimique des œuvres de nos peintres célèbres “

November 27, 2017 @ 4:00 pm
ISIS,

" De nouveaux équipements pour réaliser des analyses chimiques sur les œuvres d’art " Dr. Philippe Walter Université Pierre et Marie Curie, CNRS, Paris Philippe Walter, Directeur de recherche au CNRS, nous présentera ses nouveaux équipements et méthodes d’analyse pour caractériser la composition chimique de peintures de célèbres artistes tels que Léonard de Vinci, le Caravage et Nicolas Poussin. La nature chimique des pigments, leurs modes de préparation et leur évolution au cours du temps seront exposées.

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January 2018

Professeur Jeffrey W. BODE “New Building Block Strategies for the Synthesis of Biologically Active Organic Molecules”

January 29 @ 4:30 pm
ISIS,

Professeur Jeffrey W. BODE ETH Zurich - Dpt of Chemistry and Applied Biosciences Laboratory of Organic Chemistry http://www.bode.ethz.ch/

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February 2018

Prof. Frank GLORIUS “On discovery in photocatalysis, hydrogenation and on-surface chemistry”

February 5 @ 4:00 pm
ISIS,

Prof. Frank Glorius Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität e-mail: glorius@uni-muenster.de Catalysis is a key technology of our modern societies, since it allows for increased levels of selectivity and efficacy of chemical transformations. While significant progress can be made by rational design or engineered step-by-step improvements, many pressing challenges in the field require the discovery of new and formerly unexpected results. Arguably, the question “How to discover?” is at the heart of the scientific process. In this talk, strategies and discoveries…

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