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October 2018

Israel-Unistra Symposium in Chemistry

October 24 @ 9:00 am - 5:00 pm

Israel-Unistra Symposium in Chemistry Programme: 9:00 – 9:45 am Prof. Peter Faller (Université de Strasbourg) “Metal-binding to amyloid-beta peptides: coordination, reactivity, aggregation and biological implications” 9:55 – 10:40 am Prof. Yifat Miller (Ben-Gurion University of the Negev) “Current challenges in investigating the effect of metals in amyloid aggregation” 10:50 – 11:35 am Prof. Galia Mayaan (Technion - Israel Institute of Technology) “Bio-inspired cooperative catalysis” 11:45 – 12:30 pm Dr. Vladimir Torbeev (Université de Strasbourg) “Conformational dynamics of an intrinsically disordered…

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Dr. Lorenz Mitschang “A comprehensive model for hyperpolarized 129Xe NMR biosensing: tracking the detection limit and quantifying the sensor concentration”

October 30 @ 11:00 am - 11:00 pm

Dr. Lorenz Mitschang PTB - The National Metrology Institute of Germany Abstract: Hyperpolarized 129Xe forms in conjunction with reversibly bonded molecular host structures a formidable nuclear magnetic resonance sensor for the ultrasensitive detection of molecular and cellular markers in-vitro as well as in-vivo. To further the quantitative assessment of the method, a comprehensive model, integrating the hyperpolarization generation, the spin relaxation and the host-xenon exchange dynamics, is proposed. As demonstrated for the well-established host molecule cryptophane-A, the model enables the…

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